2009
Estrogens Regulate Posttranslational Modification of Neural Cell Adhesion Molecule during the Estrogen-Induced Gonadotropin Surge
Tan O, Fadiel A, Chang A, Demir N, Jeffrey R, Horvath T, Garcia-Segura LM, Naftolin F. Estrogens Regulate Posttranslational Modification of Neural Cell Adhesion Molecule during the Estrogen-Induced Gonadotropin Surge. Endocrinology 2009, 150: 2783-2790. PMID: 19282389, DOI: 10.1210/en.2008-0927.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEstradiolEstrogensEstrous CycleFemaleGonadotropinsMiceMice, Inbred C57BLMidline Thalamic NucleiModels, AnimalNeural Cell Adhesion Molecule L1Neural Cell Adhesion MoleculesNeuronal PlasticityProtein IsoformsProtein Processing, Post-TranslationalRNA, MessengerSialic AcidsSialyltransferasesSynapsesConceptsNeural cell adhesion moleculePeriventricular areaIR-PSAPerineural spacePSA-NCAMCell adhesion moleculeAdhesion moleculesPSA-NCAM stainingExtent of stainingSialyltransferase mRNA levelsGonadotropin surgeNCAM stainingPreovulatory gonadotropinSynaptic plasticityProestrous afternoonEstrogenWestern blotProestrusIndividual neuronsRT-PCRMetestrusMRNA levelsHypothalamus tissueStainingSialyltransferase mRNA
2007
Estrogen-Induced Hypothalamic Synaptic Plasticity and Pituitary Sensitization in the Control of the Estrogen-Induced Gonadotrophin Surge
Naftolin F, Garcia-Segura LM, Horvath TL, Zsarnovszky A, Demir N, Fadiel A, Leranth C, Vondracek-Klepper S, Lewis C, Chang A, Parducz A. Estrogen-Induced Hypothalamic Synaptic Plasticity and Pituitary Sensitization in the Control of the Estrogen-Induced Gonadotrophin Surge. Reproductive Sciences 2007, 14: 101-116. PMID: 17636222, DOI: 10.1177/1933719107301059.Peer-Reviewed Original ResearchConceptsGnRH secretionPituitary gonadotrophsGonadotrophin surgeSynaptic plasticityInsulinlike growth factor 1Triggering of ovulationOvarian estrogen secretionGrowth factor-1Neural cell adhesion moleculePituitary sensitizationGnRH cellsGnRH neuronsEstrogen secretionHypothalamic neuronsGonadal functionCell adhesion moleculeSex steroidsSpecific immunoneutralizationOvarian cycleGonadotrophsAdhesion moleculesEstrogenMaximal sensitizationSecretionFactor 1
2001
Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback.
Zsarnovszky A, Horvath T, Garcia-Segura L, Horvath B, Naftolin F. Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback. Journal Of Neuroendocrinology 2001, 13: 22-8. PMID: 11123512, DOI: 10.1046/j.1365-2826.2001.00602.x.Peer-Reviewed Original ResearchConceptsGnRH neuronesGnRH cellsDay 1Day 2Day 8Pg/Gonadotropin secretionOestrogen-induced LH surgeAfrican green monkeysInhibitory innervationEstrogen modulationOVX monkeysLH surgeArcuate nucleusSerum concentrationsExcitatory inputsInhibitory synapsesExcitatory synapsesInhibitory inputsSynaptic connectionsGnRHNeuronesGreen monkeysSynapsesPronounced alterationsOestrogen‐Induced Changes in the Synaptology of the Monkey (Cercopithecus aethiops) Arcuate Nucleus During Gonadotropin Feedback
Zsarnovszky A, Horvath TL, Garcia‐Segura L, Horvath B, Naftolin F. Oestrogen‐Induced Changes in the Synaptology of the Monkey (Cercopithecus aethiops) Arcuate Nucleus During Gonadotropin Feedback. Journal Of Neuroendocrinology 2001, 13: 22-28. DOI: 10.1111/j.1365-2826.2001.00602.x.Peer-Reviewed Original ResearchConceptsGnRH neuronesGnRH cellsDay 1Day 2Day 8Pg/Gonadotropin secretionArcuate nucleusOestrogen-induced LH surgeAfrican green monkeysGonadotropin feedbackInhibitory innervationEstrogen modulationOVX monkeysLH surgeSerum concentrationsExcitatory inputsInhibitory synapsesExcitatory synapsesInhibitory inputsSynaptic connectionsGnRHNeuronesGreen monkeysSynapses
1997
Lack of Gonadotropin-Positive Feedback in the Male Rat Is Associated with Lack of Estrogen-Induced Synaptic Plasticity in the Arcuate Nucleus
Horvath T, Garcia-Segura L, Naftolin F. Lack of Gonadotropin-Positive Feedback in the Male Rat Is Associated with Lack of Estrogen-Induced Synaptic Plasticity in the Arcuate Nucleus. Neuroendocrinology 1997, 65: 136-140. PMID: 9067991, DOI: 10.1159/000127173.Peer-Reviewed Original ResearchConceptsArcuate nucleusFemale ratsSynaptic plasticitySynaptic retractionMale ratsSynapse countsEstrogen-induced synaptic plasticityFemale arcuate nucleusVehicle-injected groupHypothalamic arcuate nucleusAdministration of estrogenAfternoon of proestrusQuantitative electron microscopic analysisOil-injected controlsGonadotropin secretionSynaptic reorganizationSynaptic countsConstant estrusEndogenous estrogensSynaptic remodelingSingle injectionTreatment groupsHormone injectionEstrogenOvarian cycleControl of gonadotropin feedback: The possible role of estrogen-induced hypothalamic synaptic plasticity
Horvath TL, Garcia-segura LM, Naftolin F. Control of gonadotropin feedback: The possible role of estrogen-induced hypothalamic synaptic plasticity. Gynecological Endocrinology 1997, 11: 139-143. PMID: 9174856, DOI: 10.3109/09513599709152525.Peer-Reviewed Original ResearchConceptsSynaptic plasticityEstrogen-induced synaptic plasticityHypothalamic arcuate nucleusPreovulatory gonadotropin surgeInhibitory synaptic connectionsGonadotropin feedbackGonadotropin surgeArcuate nucleusPreovulatory surgePituitary gonadotrophsSynaptic connectionsSecretion resultsRecent evidenceMassive releaseEstrogenPossible roleGonadotropinHypothalamusCritical eventsGonadotrophs