2004
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
Gao Q, Wolfgang MJ, Neschen S, Morino K, Horvath TL, Shulman GI, Fu XY. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 4661-4666. PMID: 15070774, PMCID: PMC384803, DOI: 10.1073/pnas.0303992101.Peer-Reviewed Original ResearchMeSH KeywordsAcute-Phase ProteinsAdipose Tissue, BrownAnimalsBody Temperature RegulationCorticosteroneDiabetes MellitusDNA-Binding ProteinsFemaleInfertility, FemaleInfertility, MaleIntermediate Filament ProteinsKineticsLeptinMaleMiceMice, KnockoutMice, TransgenicNerve Tissue ProteinsNestinObesityRatsSTAT3 Transcription FactorTime FactorsTrans-ActivatorsConceptsSignal transducerActivator of transcriptionApparent developmental abnormalitiesEnergy homeostasisGenetic modelsTranscription 3Mendelian ratioHomozygous mutantsCold stressNeonatal lethalityPhysiological roleMutantsGlial differentiationUnique phenotypeSTAT3Essential roleDevelopmental abnormalitiesHomeostasisActivatorNeuroendocrine defectsTranscriptionDisruptionProteinKnockoutReproduction
1999
Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria Predict Thermal Synapses in Homeostatic Centers
Horvath T, Warden C, Hajos M, Lombardi A, Goglia F, Diano S. Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria Predict Thermal Synapses in Homeostatic Centers. Journal Of Neuroscience 1999, 19: 10417-10427. PMID: 10575039, PMCID: PMC6782406, DOI: 10.1523/jneurosci.19-23-10417.1999.Peer-Reviewed Original ResearchConceptsC-Fos-expressing cellsPeripheral energy homeostasisHormone-releasing hormoneHypothalamic neuronal populationsCorticotropin-releasing factorMelanin-concentrating hormoneMitochondria of neuronsUCP2 proteinPeripheral hormonesProximal dendritesNeuropeptide YGonadal steroidsModulates neurotransmissionAxon terminalsBasal brainLocal brainNeuronal populationsAxonal processesNeuronal mitochondriaPeptidergic circuitsBrain circuitsEnergy homeostasisCold exposureNeuronsEndocrine processes