2010
Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
Horvath TL, Sarman B, García-Cáceres C, Enriori PJ, Sotonyi P, Shanabrough M, Borok E, Argente J, Chowen JA, Perez-Tilve D, Pfluger PT, Brönneke HS, Levin BE, Diano S, Cowley MA, Tschöp MH. Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14875-14880. PMID: 20679202, PMCID: PMC2930476, DOI: 10.1073/pnas.1004282107.Peer-Reviewed Original ResearchConceptsHigh-fat dietSynaptic input organizationReactive gliosisPOMC neuronsDIO ratsDR ratsArcuate nucleusMelanocortin systemPOMC cellsNeuropeptide Y cellsInput organizationLoss of synapsesDiet-induced obesityBlood-brain barrierHFD-fed animalsDIO animalsAnorexigenic proopiomelanocortinGlial ensheathmentSynaptic organizationInhibitory inputsLean ratsDR animalsNeuronal circuitsCell bodiesGliosis
1995
Estrogen-induced hypothalamic synaptic plasticity and the regulation of gonadotrophins
Horvath T, Leedom L, Lewis C, Garcia-Segura L, Naftolin F. Estrogen-induced hypothalamic synaptic plasticity and the regulation of gonadotrophins. Current Opinion In Endocrinology Diabetes And Obesity 1995, 2: 186. DOI: 10.1097/00060793-199504000-00018.Peer-Reviewed Original ResearchSynaptic plasticityNumber of synapseRegulation of gonadotrophinBasal estrogen levelsUnderstanding of estrogenGonadotrophin controlSynaptic retractionEstrogen surgeGonadotrophin levelsEstrogen levelsPreovulatory riseArcuate nucleusGlial ensheathmentNeuronal perikaryaGlial cellsNeurotransmitter effectsEstrogenEstrogen inducesNegative feedback controlGonadotrophinPossible mechanismRetractionHypothalamusPerikaryaLevels