2022
A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice
Korchynska S, Rebernik P, Pende M, Boi L, Alpár A, Tasan R, Becker K, Balueva K, Saghafi S, Wulff P, Horvath TL, Fisone G, Dodt HU, Hökfelt T, Harkany T, Romanov RA. A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice. Nature Communications 2022, 13: 5944. PMID: 36209152, PMCID: PMC9547883, DOI: 10.1038/s41467-022-33584-3.Peer-Reviewed Original ResearchConceptsLateral septumDopamine neuronsSuprachiasmatic nucleusSomatostatin-containing neuronsStimulation ex vivoAmphetamine-induced hyperlocomotionRegulation of locomotionDopamine outputChemogenetic inhibitionNeuropeptidergic innervationPeriventricular nucleusChemogenetic manipulationHypothalamic lociSynaptic targetsAnterior subdivisionEx vivoBrain clockNeuronsSedentary periodL activityHyperlocomotionCellular targetsMicePeVNInnervation
2019
Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity
Stutz B, Nasrallah C, Nigro M, Curry D, Liu ZW, Gao XB, Elsworth JD, Mintz L, Horvath TL. Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity. Molecular Metabolism 2019, 24: 120-138. PMID: 30833218, PMCID: PMC6531791, DOI: 10.1016/j.molmet.2019.02.005.Peer-Reviewed Original ResearchConceptsSN DA neuronsDA neuronsSubstantia nigraDA cellsDopamine outputNeuronal protectionNeuronal survivalParkinson's diseaseDA neuron survivalDA neuronal survivalDesigner drugs (DREADD) technologyNeuronal pacemaker activityElectrical activityMouse substantia nigraElectric activityNeuron electrical activityAnimal motor behaviorGhrelin activationGHSR activationTetrahydropyridine (MPTP) treatmentNeuroprotective factorsNeuron survivalDopamine neuronsGhrelin receptorExogenous administration
2016
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow AK, Martens H, Schwindling C, Calvigioni D, Bains JS, Máté Z, Szabó G, Yanagawa Y, Zhang MD, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath TL, Harkany T. Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes. Nature Neuroscience 2016, 20: 176-188. PMID: 27991900, PMCID: PMC7615022, DOI: 10.1038/nn.4462.Peer-Reviewed Original Research
2006
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. Journal Of Clinical Investigation 2006, 116: 3229-3239. PMID: 17060947, PMCID: PMC1618869, DOI: 10.1172/jci29867.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAppetiteDopamineFluorescent Antibody TechniqueGhrelinMaleMesencephalonMiceMice, Inbred C57BLMice, KnockoutNeuronsNucleus AccumbensPatch-Clamp TechniquesPeptide HormonesRatsRats, Sprague-DawleyReceptors, GhrelinReceptors, G-Protein-CoupledTime FactorsVentral Tegmental AreaConceptsVentral tegmental areaGHSR-deficient miceGHSR-dependent mannerGut hormone ghrelinDopamine neuronal activityMidbrain dopamine neuronsMesolimbic reward circuitrySynaptic input organizationPeripheral ghrelinRebound feedingVTA administrationOrexigenic effectDopamine turnoverGHSR antagonistDopamine neuronsHypothalamic centersTegmental areaHormone ghrelinNucleus accumbensGhrelinNeuronal activitySynapse formationReward circuitryInput organizationFeeding schedule
2003
Coenzyme Q Induces Nigral Mitochondrial Uncoupling and Prevents Dopamine Cell Loss in a Primate Model of Parkinson’s Disease
Horvath TL, Diano S, Leranth C, Garcia-Segura LM, Cowley MA, Shanabrough M, Elsworth JD, Sotonyi P, Roth RH, Dietrich EH, Matthews RT, Barnstable CJ, Redmond DE. Coenzyme Q Induces Nigral Mitochondrial Uncoupling and Prevents Dopamine Cell Loss in a Primate Model of Parkinson’s Disease. Endocrinology 2003, 144: 2757-2760. PMID: 12810526, DOI: 10.1210/en.2003-0163.Peer-Reviewed Original ResearchConceptsDopamine cell lossParkinson's diseaseCell lossShort-term oral administrationMitochondrial uncouplingSubstantia nigraDopamine neuronsTetrahydropyridine (MPTP) administrationCoenzyme QPrimate modelOral administrationDiseaseOxidative stressState 4 respirationMitochondrial uncoupling proteinAdministrationUncoupling proteinUncouplingNeuronsNigraTetrahydropyridine
2000
Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory
Leranth C, Roth R, Elsworth J, Naftolin F, Horvath T, Redmond D. Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory. Journal Of Neuroscience 2000, 20: 8604-8609. PMID: 11102464, PMCID: PMC6773080, DOI: 10.1523/jneurosci.20-23-08604.2000.Peer-Reviewed Original ResearchConceptsNigrostriatal dopamine neuronsDopamine neuronsParkinson's diseaseSubstantia nigraDopamine cellsTyrosine hydroxylase-expressing neuronsTyrosine hydroxylase-immunoreactive cellsNigral dopamine systemsEstrogen replacement therapyNew treatment strategiesUnbiased stereological analysisTypes of neuronsProgression of diseaseEstrogen replacementPostmenopausal womenEstrogen deprivationReplacement therapyTreatment strategiesCompact zoneGonadal hormonesLong-term effectsDopamine systemEstrogenDiseaseNeurons
1998
An Alternate Pathway for Visual Signal Integration into the Hypothalamo-Pituitary Axis: Retinorecipient Intergeniculate Neurons Project to Various Regions of the Hypothalamus and Innervate Neuroendocrine Cells Including Those Producing Dopamine
Horvath TL. An Alternate Pathway for Visual Signal Integration into the Hypothalamo-Pituitary Axis: Retinorecipient Intergeniculate Neurons Project to Various Regions of the Hypothalamus and Innervate Neuroendocrine Cells Including Those Producing Dopamine. Journal Of Neuroscience 1998, 18: 1546-1558. PMID: 9454860, PMCID: PMC6792709, DOI: 10.1523/jneurosci.18-04-01546.1998.Peer-Reviewed Original ResearchConceptsHypothalamo-pituitary axisIntergeniculate leafletNeuroendocrine cellsSuprachiasmatic nucleusHypothalamic dopamine neuronsMedial preoptic areaFenestrated capillariesPopulations of neuronsNeurons projectBilateral enucleationHypothalamic projectionsDistal dendritesRetrograde tracerVentromedial nucleusDopamine neuronsIntraperitoneal injectionProjection sitesPeriventricular nucleusPreoptic areaRetinal fibersTract tracingHypothalamic cellsRetinal axonsSynaptic targetsEfferents
1993
Neuropeptide-Y innervation of estrogen-induced progesterone receptor-containing dopamine cells in the monkey hypothalamus: a triple labeling light and electron microscopic study
Horvath T, Shanabrough M, Naftolin F, Leranth C. Neuropeptide-Y innervation of estrogen-induced progesterone receptor-containing dopamine cells in the monkey hypothalamus: a triple labeling light and electron microscopic study. Endocrinology 1993, 133: 405-414. DOI: 10.1210/en.133.1.405.Peer-Reviewed Original ResearchTyrosine hydroxylase-immunoreactive neuronsNPY-immunoreactive axon terminalsProgesterone receptorNeuropeptide-YDopamine cellsFrequency of synaptic contactsLight brown diaminobenzidine reactionTyrosine hydroxylase-immunopositive cellsNPY-immunoreactive boutonsPR-containing cellsSynaptic contactsNuclear progesterone receptorDorsomedial hypothalamic nucleusEstrogen-treated monkeysHypophyseal hormone secretionAxon terminalsEffects of neuropeptide-YCoronal vibratome sectionsAfrican green monkeysPRL releaseOVX animalsDopamine neuronsMonkey hypothalamusHormone secretionHypothalamic nucleiNeuropeptide-Y innervation of estrogen-induced progesterone receptor-containing dopamine cells in the monkey hypothalamus: a triple labeling light and electron microscopic study
Horvath TL, Shanabrough M, Naftolin F, Leranth C. Neuropeptide-Y innervation of estrogen-induced progesterone receptor-containing dopamine cells in the monkey hypothalamus: a triple labeling light and electron microscopic study. Endocrinology 1993, 133: 405-414. PMID: 8100520, DOI: 10.1210/endo.133.1.8100520.Peer-Reviewed Original ResearchConceptsTyrosine hydroxylase-immunoreactive neuronsHydroxylase-immunoreactive neuronsProgesterone receptorSynaptic contactsAxon terminalsDopamine cellsTyrosine hydroxylase-immunopositive cellsHypophyseal hormone secretionEffects of NPYDorsomedial hypothalamic nucleusCoronal vibratome sectionsNuclear progesterone receptorPR-containing cellsAfrican green monkeysDiaminobenzidine reactionNPY axonsPeriventricular areaOVX animalsHormone secretionMonkey hypothalamusAnterior hypothalamusHypothalamic nucleiDopamine neuronsPRL releaseEstrogen
1992
Beta-endorphin innervation of dopamine neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study
Horvath TL, Naftolin F, Leranth C. Beta-endorphin innervation of dopamine neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study. Endocrinology 1992, 131: 1547-1555. PMID: 1354605, DOI: 10.1210/endo.131.3.1354605.Peer-Reviewed Original ResearchConceptsDopamine neuronsZona incertaDopamine cellsSynaptic connectionsCell bodiesDouble immunostaining experimentsHypophyseal hormone secretionHypothalamic dopaminergic systemFemale rat brainHypothalamic dopaminergic neuronsDorsomedial hypothalamic nucleusDopamine cell bodiesReceptor-containing cellsDouble immunostaining studiesLight microscopic examinationPutative synaptic connectionsLH releaseDopamine innervationImmunoreactive boutonsPeriventricular areaDopaminergic neuronsPRL secretionSynaptic contactsArcuate nucleusHormone secretion