2013
Homeostatic Control of Synaptic Transmission by Distinct Glutamate Receptors
Yan D, Yamasaki M, Straub C, Watanabe M, Tomita S. Homeostatic Control of Synaptic Transmission by Distinct Glutamate Receptors. Neuron 2013, 78: 687-699. PMID: 23719165, PMCID: PMC3668311, DOI: 10.1016/j.neuron.2013.02.031.Peer-Reviewed Original ResearchConceptsKainate receptor activityGlutamate receptorsReceptor activitySynaptic transmissionNeuronal activityHigh-affinity kainate receptor subunitKainate receptor-mediated currentsDistinct glutamate receptorsReceptor-mediated currentsAMPA receptor activitySynaptic AMPA receptorsPostsynaptic glutamate receptorsKainate receptor subunitsAbundant excitatory neurotransmitterCerebellar granule cellsReceptor channel propertiesExcitatory neurotransmitterNMDA receptorsAMPA receptorsGranule cellsReceptor subunitsReceptorsSpike generationHomeostatic controlGluK5 subunits
2010
TARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers
Sumioka A, Yan D, Tomita S. TARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers. Neuron 2010, 66: 755-767. PMID: 20547132, PMCID: PMC2887694, DOI: 10.1016/j.neuron.2010.04.035.Peer-Reviewed Original ResearchConceptsAMPA receptor activityTransmembrane AMPA receptor regulatory proteinsReceptor activityGlutamate receptorsSynaptic transmissionAMPA receptorsAMPA receptor-mediated synaptic transmissionPredominant excitatory neurotransmitter receptorsReceptor-mediated synaptic transmissionAMPA-type glutamate receptorsSynaptic AMPA receptorsFast synaptic transmissionIonotropic glutamate receptorsExcitatory neurotransmitter receptorsReceptor regulatory proteinsNeuronal activityNeurotransmitter receptorsPSD-95Synaptic strengthNeural circuitsReceptorsPhosphorylation-dependent mannerStargazinSynapsesTarp phosphorylation
2009
A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamate Receptors
Zhang W, St-Gelais F, Grabner CP, Trinidad JC, Sumioka A, Morimoto-Tomita M, Kim KS, Straub C, Burlingame AL, Howe JR, Tomita S. A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamate Receptors. Neuron 2009, 61: 385-396. PMID: 19217376, PMCID: PMC2803770, DOI: 10.1016/j.neuron.2008.12.014.Peer-Reviewed Original ResearchConceptsKainate-type glutamate receptorsGlutamate receptorsIonotropic glutamate receptorsKainate receptorsSynaptic transmissionSurface expressionNative kainate receptorsFast synaptic transmissionKainate receptor subunitsBrain-specific proteinsExcitatory transmissionNMDA receptorsAMPA receptorsReceptor subunitsReceptorsProtein levelsNETO2Auxiliary subunitsTARP auxiliary subunitsBrainVertebrate brainKainate receptor GluR6Proteomic screenMajor roleMEPSCs