2022
Genetic Variants of Glucose-6-Phosphate Dehydrogenase and Their Associated Enzyme Activity: A Systematic Review and Meta-Analysis
Pfeffer DA, Satyagraha AW, Sadhewa A, Alam MS, Bancone G, Boum Y, Brito M, Cui L, Deng Z, Domingo GJ, He Y, Khan WA, Kibria MG, Lacerda M, Menard D, Monteiro W, Pal S, Parikh S, Roca-Feltrer A, Roh M, Sirdah MM, Wang D, Huang Q, Howes RE, Price RN, Ley B. Genetic Variants of Glucose-6-Phosphate Dehydrogenase and Their Associated Enzyme Activity: A Systematic Review and Meta-Analysis. Pathogens 2022, 11: 1045. PMID: 36145477, PMCID: PMC9502867, DOI: 10.3390/pathogens11091045.Peer-Reviewed Original ResearchSystematic reviewMedian activityDrug-induced haemolysisG6PD activityIndividual patient dataGenetic variantsGlucose-6-phosphate dehydrogenase enzyme activityStudy-specific definitionsMeta-AnalysisG6PD genotypeNormal activityPatient dataRelevant genetic variantsDifferent genetic variantsEnzymatic deficiencyGlucose-6-phosphate dehydrogenaseEnzyme activityVanua LavaAssociated enzyme activitiesG6PD mutationsViangchanDehydrogenase enzyme activityCurrent classification
2004
Host polymorphisms and the incidence of malaria in Ugandan children.
PARIKH S, Dorsey G, ROSENTHAL PJ. Host polymorphisms and the incidence of malaria in Ugandan children. American Journal Of Tropical Medicine And Hygiene 2004, 71: 750-3. PMID: 15642965, DOI: 10.4269/ajtmh.2004.71.750.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseWild-type childrenUgandan childrenLower incidenceHost polymorphismsParasite densityNitric oxide synthaseLow parasite densitiesIncidence of malariaHigh parasite densitySymptomatic malariaUncomplicated malariaTumor necrosisIncidence rateOxide synthaseHigh incidencePromoter polymorphismGlucose-6-phosphate dehydrogenase AMale hemizygotesMalariaIncidencePreventative measuresGlucose-6-phosphate dehydrogenaseSickle hemoglobinDehydrogenase A