2020
Gene therapy and immunotherapy as promising strategies to combat Huntington’s disease-associated neurodegeneration: emphasis on recent updates and future perspectives
Jamwal S, Elsworth JD, Rahi V, Kumar P. Gene therapy and immunotherapy as promising strategies to combat Huntington’s disease-associated neurodegeneration: emphasis on recent updates and future perspectives. Expert Review Of Neurotherapeutics 2020, 20: 1123-1141. PMID: 32720531, DOI: 10.1080/14737175.2020.1801424.Peer-Reviewed Original ResearchConceptsGene therapyClinical trialsDisease-modifying therapiesMutant huntingtinTreatment of HDAntibody-based therapiesPotential therapeutic interventionsNew therapeutic targetsGene-based therapiesImmune activationClinical dataImmunotherapyTherapeutic targetFunctional restorationTherapeutic interventionsTherapyHD pathogenesisMHTT proteinRecent updatesFuture perspectivesPromising strategyTrialsCurrent statusConsiderable attentionHD
2018
Management of HD: Insight into Molecular Mechanisms and Potential Neuroprotective Drug Strategies
Kumar P, Jamwal S, Kumar A. Management of HD: Insight into Molecular Mechanisms and Potential Neuroprotective Drug Strategies. 2018, 197-206. DOI: 10.1007/978-981-13-0944-1_18.Peer-Reviewed Original ResearchManagement of HDAnti-inflammatory agentsMedium spiny neuronsHuntington's diseaseMutant huntingtin proteinPathophysiology of HDGABAergic medium spiny neuronsTreatment of HDSpecific neurodegenerative processesFuture therapeutic targetsUse of antioxidantsMolecular mechanismsBasal gangliaSpiny neuronsNeurodegenerative processesHD subjectsPathogenic mechanismsTherapeutic targetRelated pathogenesisClinical practiceRare typeNeurodegenerative disordersPathway dysregulationDrug strategiesOxidative stress
2015
Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats
Kaur N, Jamwal S, Deshmukh R, Gauttam V, Kumar P. Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats. Toxicology Reports 2015, 2: 1222-1232. PMID: 28962465, PMCID: PMC5598492, DOI: 10.1016/j.toxrep.2015.08.004.Peer-Reviewed Original ResearchHuntington's diseaseEthanol extractTreatment of HDBeneficial effectsNon-motor dysfunctionPro-inflammatory mediatorsMedium spiny neuronsExperimental Huntington's diseaseMitochondrial functionRice bran extractBehavioral parametersProphylactic therapyNeurochemical estimationsNeurochemical alterationsProgressive motorPresent studySpiny neuronsAnimal modelsNeurochemical levelsOxidative burdenNeurodegenerative disordersBran extractDiseaseMitochondrial dysfunctionSignificant alterations