2020
Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters
Thakur V, Jamwal S, Kumar M, Rahi V, Kumar P. Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters. Neurotoxicity Research 2020, 38: 359-369. PMID: 32506340, DOI: 10.1007/s12640-020-00231-y.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dihydroxyphenylacetic AcidAnimalsAnxietyBehavior, AnimalBrainDisease Models, AnimalDopamineElectron Transport Complex IElectron Transport Complex IIElevated Plus Maze TestEnzyme InhibitorsFatigue Syndrome, ChronicGlutathioneHand StrengthHeme Oxygenase-1HeminHomovanillic AcidHydroxyindoleacetic AcidLipid PeroxidationLocomotionMetalloporphyrinsMiceMitochondriaNeurotransmitter AgentsNitritesNorepinephrineProtoporphyrinsSerotoninConceptsChronic fatigue syndromeMitochondrial complex dysfunctionFatigue syndromeProtective effectComplex dysfunctionMale albino miceAnxiety-like behaviorFatigue-like behaviorAntifatigue effectNeurotransmitter alterationsCommon symptomsPresent studyNeurotransmitter levelsSwimming testAlbino miceExperimental miceImmobility periodEnzyme inhibitorsProtective roleCognitive impairmentLocomotor activityBehavioral testsSwimming sessionBiochemical parametersBiochemical alterations
2019
Protective Effect of Agomelatine on Traumatic Brain Injury Induced Cognitive Deficit in Rats: Possible Role of Neurotransmitters
Kaur T, Kumar P, Jamwal S. Protective Effect of Agomelatine on Traumatic Brain Injury Induced Cognitive Deficit in Rats: Possible Role of Neurotransmitters. Current Psychopharmacologye 2019, 7: 192-207. DOI: 10.2174/2211556007666180601100641.Peer-Reviewed Original Research
2017
L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level
Jamwal S, Singh S, Gill JS, Kumar P. L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level. European Journal Of Pharmacology 2017, 811: 171-179. PMID: 28624333, DOI: 10.1016/j.ejphar.2017.06.016.Peer-Reviewed Original ResearchConceptsStriatal neurotransmitter levelsOxido-nitrosative stressNeurotransmitter levelsProtective effectL-NAMEMotor deficitsQuinolinic acidL-arginineL-theanineNitric oxide synthase inhibitorPro-inflammatory cytokinesNitric oxide pathwayOxide synthase inhibitorOpen field testL-theanine treatmentRota-rodBeam walkingNeuro-inflammationNeurotransmitter alterationsNeuroprotective potentialStriatal neurotoxicityOxide pathwayQA injectionGrip strengthMotor coordination
2016
L-theanine, a Component of Green Tea Prevents 3-Nitropropionic Acid (3-NP)-Induced Striatal Toxicity by Modulating Nitric Oxide Pathway
Jamwal S, Kumar P. L-theanine, a Component of Green Tea Prevents 3-Nitropropionic Acid (3-NP)-Induced Striatal Toxicity by Modulating Nitric Oxide Pathway. Molecular Neurobiology 2016, 54: 2327-2337. PMID: 26957301, DOI: 10.1007/s12035-016-9822-5.Peer-Reviewed Original ResearchConceptsHuntington's diseaseStriatal toxicityL-NAMENeuroprotective potentialConcurrent treatmentProtective effectBody weightL-arginineL-theanineGABAergic medium spiny neuronsGreen tea preventsStriatal neurotransmitter levelsPro-inflammatory mediatorsPro-inflammatory cytokinesNitric oxide pathwayBlood-brain barrierMedium spiny neuronsNitric oxide productionL-theanine treatmentNeurotransmitter alterationsOxide pathwayBrain barrierSpiny neuronsNeurotransmitter levelsRat striatum
2015
Beneficial effects of lycopene against haloperidol induced orofacial dyskinesia in rats: Possible neurotransmitters and neuroinflammation modulation
Datta S, Jamwal S, Deshmukh R, Kumar P. Beneficial effects of lycopene against haloperidol induced orofacial dyskinesia in rats: Possible neurotransmitters and neuroinflammation modulation. European Journal Of Pharmacology 2015, 771: 229-235. PMID: 26712377, DOI: 10.1016/j.ejphar.2015.12.032.Peer-Reviewed Original ResearchConceptsOrofacial dyskinesiaHaloperidol treatmentChronic neuroleptic treatmentAbnormal involuntary movementsSevere side effectsNeuroinflammatory modulationNeuroleptic treatmentTardive dyskinesiaProtective effectInvoluntary movementsSide effectsDyskinesiaBiochemical parametersHaloperidolRatsTreatmentDaysLycopeneStriatumPiperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism
Singh S, Jamwal S, Kumar P. Piperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism. Neurochemical Research 2015, 40: 1758-1766. PMID: 26160706, DOI: 10.1007/s11064-015-1658-2.Peer-Reviewed Original ResearchConceptsProtective effectPresence of piperineChronic treatmentMotor deficitsNeuroprotective effectsNeurochemical abnormalitiesAbstract3-Nitropropionic acidPresent studyInduced neurotoxicityMotor functionNeuroprotective activityBody weightMolecular alterationsBeneficial effectsHuntington's diseaseOxidative stressNatural polyphenolNeurotoxicityCurcuminPiperineRatsDiseaseAdministrationBehavioral parametersDays