2023
Animal models of Huntington’s disease and their applicability to novel drug discovery and development
Upadhayay S, Jamwal S, Kumar P. Animal models of Huntington’s disease and their applicability to novel drug discovery and development. Expert Opinion On Drug Discovery 2023, 18: 527-538. PMID: 37042034, DOI: 10.1080/17460441.2023.2201493.Peer-Reviewed Original ResearchConceptsHD animal modelsAnimal modelsHuntington's diseaseNon-motor symptomsProgressive neurodegenerative disorderDrug therapyDisease progressionPreclinical phaseLoss of functionNeurodegenerative disordersClinical phaseDrug discoveryDiseaseNovel drug discoveryHuntingtin geneToxic gainCAG trinucleotide repeatDrugsProgressionHD geneEnormous progression
2017
Animal Models of Parkinson’s Disease
Sharma N, Jamwal S, Singh S, Gill H, Bansal P. Animal Models of Parkinson’s Disease. 2017, 23-42. DOI: 10.1007/978-981-10-5981-0_3.Peer-Reviewed Original ResearchParkinson's diseaseDopaminergic neuronsLewy bodiesPrevalence of PDCranial nerve motor nucleiHypokinetic movement disordersNigrostriatal dopaminergic neuronsNon-motor symptomsMajor pathological featureAge related neurodegenerative diseasesRelated neurodegenerative diseasesInheritable genetic mutationsProgressive neurodegenerativeAutonomic dysfunctionOrthostatic hypotensionIdiopathic originNeuropsychiatric disturbancesCerebral cortexMotor manifestationsMotor nucleusNucleus basalisPathological featuresSleep disturbancesLocus coeruleusSelective degeneration