2024
A review on polyamines as promising next-generation neuroprotective and anti-aging therapy
Arthur R, Jamwal S, Kumar P. A review on polyamines as promising next-generation neuroprotective and anti-aging therapy. European Journal Of Pharmacology 2024, 978: 176804. PMID: 38950837, DOI: 10.1016/j.ejphar.2024.176804.Peer-Reviewed Original ResearchCognitive dysfunctionNeurodegenerative disordersRegulation of gene expressionProgressive degeneration of neuronsProgrammed cell deathDegeneration of neuronsSymptomatic therapyPharmacological strategiesAnti-oxidative effectsAnti-aging therapyAverage ageProgressive degenerationNeuroprotective effectsLocomotor abnormalitiesIon channelsCell deathBiochemical activityGene expressionPopulation average ageTherapyMolecular mechanismsDisordersPolyamine supplementationDysfunctionAnti-aging effects
2023
Animal models of Huntington’s disease and their applicability to novel drug discovery and development
Upadhayay S, Jamwal S, Kumar P. Animal models of Huntington’s disease and their applicability to novel drug discovery and development. Expert Opinion On Drug Discovery 2023, 18: 527-538. PMID: 37042034, DOI: 10.1080/17460441.2023.2201493.Peer-Reviewed Original ResearchConceptsHD animal modelsAnimal modelsHuntington's diseaseNon-motor symptomsProgressive neurodegenerative disorderDrug therapyDisease progressionPreclinical phaseLoss of functionNeurodegenerative disordersClinical phaseDrug discoveryDiseaseNovel drug discoveryHuntingtin geneToxic gainCAG trinucleotide repeatDrugsProgressionHD geneEnormous progression
2021
Expression of PON2 isoforms varies among brain regions in male and female African green monkeys
Jamwal S, Blackburn JK, Elsworth JD. Expression of PON2 isoforms varies among brain regions in male and female African green monkeys. Free Radical Biology And Medicine 2021, 178: 215-218. PMID: 34890766, PMCID: PMC8760629, DOI: 10.1016/j.freeradbiomed.2021.12.005.Peer-Reviewed Original ResearchConceptsAfrican green monkeysParkinson's diseaseBrain regionsParaoxonase 2Different brain regionsFemale monkeysGreen monkeysPON2 expressionOxidative stress-related neurodegenerative disordersFemale African green monkeysNeurodegenerative disordersMale African green monkeysOxidative stressPON2 protein expressionAnti-inflammatory propertiesExpression levelsSignificant differencesBrain tissue samplesDorsolateral prefrontal cortexNeuroprotective strategiesWestern blotting techniquesDopaminergic neuronsPON2 proteinPrimate brainProtective roleSex-based disparity in paraoxonase-2 expression in the brains of African green monkeys
Jamwal S, Blackburn JK, Elsworth JD. Sex-based disparity in paraoxonase-2 expression in the brains of African green monkeys. Free Radical Biology And Medicine 2021, 167: 201-204. PMID: 33722626, PMCID: PMC8096713, DOI: 10.1016/j.freeradbiomed.2021.03.003.Peer-Reviewed Original ResearchConceptsAfrican green monkeysParaoxonase 2Parkinson's diseaseBrain regionsGreen monkeysOxidative stressReactive oxygen speciesAnti-inflammatory propertiesSex-based disparitiesParaoxonase-2 expressionDifferent brain regionsNigrostriatal systemPON2 expressionDevelopment of therapeuticsNeurodegenerative disordersDiseaseProtein levelsROS levelsLower ROS levelsMitochondrial performanceSex-based variationDisordersMonkeysOxygen speciesMales
2020
PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders
Jamwal S, Blackburn J, Elsworth JD. PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders. Pharmacology & Therapeutics 2020, 219: 107705. PMID: 33039420, PMCID: PMC7887032, DOI: 10.1016/j.pharmthera.2020.107705.Peer-Reviewed Original ResearchConceptsNeurodegenerative disordersParkinson's diseaseAlzheimer's diseaseParaoxonase 2Mitochondrial biogenesisNeurodegenerative diseasesHuntington's diseasePeroxisome proliferator-activated receptorProliferator-activated receptorPotential therapeutic targetDevastating neurological disorderFunction of neuronsPeroxisome proliferator-activated receptor gamma co-activator-1 alphaPharmacological-based therapiesSymptomatic treatmentCurrent therapiesClinical trialsLigand-inducible transcription factorsTherapeutic targetNeurological disordersDiseasePPARγ modulatorsProgressive lossMitochondrial dysfunctionPromising target
2018
Management of HD: Insight into Molecular Mechanisms and Potential Neuroprotective Drug Strategies
Kumar P, Jamwal S, Kumar A. Management of HD: Insight into Molecular Mechanisms and Potential Neuroprotective Drug Strategies. 2018, 197-206. DOI: 10.1007/978-981-13-0944-1_18.Peer-Reviewed Original ResearchManagement of HDAnti-inflammatory agentsMedium spiny neuronsHuntington's diseaseMutant huntingtin proteinPathophysiology of HDGABAergic medium spiny neuronsTreatment of HDSpecific neurodegenerative processesFuture therapeutic targetsUse of antioxidantsMolecular mechanismsBasal gangliaSpiny neuronsNeurodegenerative processesHD subjectsPathogenic mechanismsTherapeutic targetRelated pathogenesisClinical practiceRare typeNeurodegenerative disordersPathway dysregulationDrug strategiesOxidative stress
2017
Animal Model of Amyotrophic Lateral Sclerosis
Koshal P, Kumar M, Jamwal S, Bansal P. Animal Model of Amyotrophic Lateral Sclerosis. 2017, 277-289. DOI: 10.1007/978-981-10-5981-0_18.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosisMotor neuronsLateral sclerosisMuscle performancePatients of ALSPrevalence of ALSCases of ALSDepletion of neuronsUpper motor neuronsLower motor neuronsFamilial amyotrophic lateral sclerosisInvolvement of neuronsLou Gehrig's diseaseALS-dementiaCerebral cortexMuscle weaknessSubstantia nigraBrain stemDisease progressionSpinal cordMuscle atrophyAnimal modelsAverage ageCognitive impairmentNeurodegenerative disorders
2016
Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats
Sharma N, Jamwal S, Kumar P. Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats. Pathophysiology 2016, 23: 123-134. PMID: 26996500, DOI: 10.1016/j.pathophys.2016.03.002.Peer-Reviewed Original ResearchRotenone administrationCommon age-related neurodegenerative disorderDay one hourPro-inflammatory mediatorsAge-related neurodegenerative disordersLevels of catecholaminesTreatment of PDPathogenesis of PDLevodopa combinationAdjuvant therapyDA neuronsNeuroprotective roleCatecholamine levelsDifferent antidepressantsNeurotransmitter dysfunctionCNS disordersParkinson's diseaseMotor coordinationBody weightAntidepressantsSNpc regionNeurodegenerative disordersParkinsonismBeneficial effectsSertraline
2015
Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters
Jamwal S, Kumar P. Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters. Physiology & Behavior 2015, 155: 180-187. PMID: 26703234, DOI: 10.1016/j.physbeh.2015.12.015.Peer-Reviewed Original ResearchConceptsHuntington's diseaseStriatal toxicityStriatal neurotransmittersRat striatumMotor coordinationPro-inflammatory cytokine levelsOxidative stressPro-inflammatory mediatorsPotential neuroprotective effectsAnti-inflammatory propertiesGood experimental modelConfer neuroprotectionCytokine levelsNeuroinflammatory markersNeuroprotective effectsPresent studyNeurochemical analysisBody weightTherapeutic potentialNeurodegenerative disordersBiochemical parametersExperimental modelDecreased levelsNeurotransmittersSignificant alterationsBeneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats
Kaur N, Jamwal S, Deshmukh R, Gauttam V, Kumar P. Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats. Toxicology Reports 2015, 2: 1222-1232. PMID: 28962465, PMCID: PMC5598492, DOI: 10.1016/j.toxrep.2015.08.004.Peer-Reviewed Original ResearchHuntington's diseaseEthanol extractTreatment of HDBeneficial effectsNon-motor dysfunctionPro-inflammatory mediatorsMedium spiny neuronsExperimental Huntington's diseaseMitochondrial functionRice bran extractBehavioral parametersProphylactic therapyNeurochemical estimationsNeurochemical alterationsProgressive motorPresent studySpiny neuronsAnimal modelsNeurochemical levelsOxidative burdenNeurodegenerative disordersBran extractDiseaseMitochondrial dysfunctionSignificant alterations
2014
Neuroprotective effect of hemeoxygenase-1/glycogen synthase kinase-3β modulators in 3-nitropropionic acid-induced neurotoxicity in rats
Khan A, Jamwal S, Bijjem K, Prakash A, Kumar P. Neuroprotective effect of hemeoxygenase-1/glycogen synthase kinase-3β modulators in 3-nitropropionic acid-induced neurotoxicity in rats. Neuroscience 2014, 287: 66-77. PMID: 25536048, DOI: 10.1016/j.neuroscience.2014.12.018.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody WeightCorpus StriatumEncephalitisGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHeme Oxygenase-1HeminLipid PeroxidationLithium ChlorideMaleMetalloporphyrinsMotor ActivityNeuroprotective AgentsNeurotoxicity SyndromesNitritesNitro CompoundsOxidative StressPropionatesProtoporphyrinsRatsRats, WistarRotarod Performance TestSignal TransductionConceptsAdministration of heminHemeoxygenase-1GSK-3β activityN-methyl-D-aspartate receptorsOxidative stressPro-inflammatory mediatorsPresent studyHO-1 inhibitorGSK-3β pathwaySynthase kinase-3β pathwayDifferent neurodegenerative disordersHD-like symptomsProphylactic therapyNeuroprotective effectsPathophysiology of HDTin protoporphyrinMotor impairmentPharmacological modulationMotor coordinationBody weightLocomotor activityMolecular alterationsTherapeutic potentialOxidative burdenNeurodegenerative disorders