2018
Management of HD: Insight into Molecular Mechanisms and Potential Neuroprotective Drug Strategies
Kumar P, Jamwal S, Kumar A. Management of HD: Insight into Molecular Mechanisms and Potential Neuroprotective Drug Strategies. 2018, 197-206. DOI: 10.1007/978-981-13-0944-1_18.Peer-Reviewed Original ResearchManagement of HDAnti-inflammatory agentsMedium spiny neuronsHuntington's diseaseMutant huntingtin proteinPathophysiology of HDGABAergic medium spiny neuronsTreatment of HDSpecific neurodegenerative processesFuture therapeutic targetsUse of antioxidantsMolecular mechanismsBasal gangliaSpiny neuronsNeurodegenerative processesHD subjectsPathogenic mechanismsTherapeutic targetRelated pathogenesisClinical practiceRare typeNeurodegenerative disordersPathway dysregulationDrug strategiesOxidative stress
2015
Antidepressants for neuroprotection in Huntington's disease: A review
Jamwal S, Kumar P. Antidepressants for neuroprotection in Huntington's disease: A review. European Journal Of Pharmacology 2015, 769: 33-42. PMID: 26511378, DOI: 10.1016/j.ejphar.2015.10.033.Peer-Reviewed Original ResearchConceptsHuntingtin proteinHuntington's diseaseMAPK/ERK signalingBrain-derived neurotrophic factor (BDNF) productionBDNF/TrkB pathwayProgression of HDDifferent neuroprotective mechanismsPrincipal neuropathological hallmarksUse of antidepressantsNeurotrophic factor productionCortical projection neuronsMutant huntingtin proteinCellular functionsPolyglutamine stretchMolecular mechanismsNH2 terminusERK signalingTrkB pathwayPreclinical evidenceNeuroprotective effectsNeuroprotective mechanismsCommon symptomsProjection neuronsAvailable treatmentsDisease progression