2023
Animal models of Huntington’s disease and their applicability to novel drug discovery and development
Upadhayay S, Jamwal S, Kumar P. Animal models of Huntington’s disease and their applicability to novel drug discovery and development. Expert Opinion On Drug Discovery 2023, 18: 527-538. PMID: 37042034, DOI: 10.1080/17460441.2023.2201493.Peer-Reviewed Original ResearchConceptsHD animal modelsAnimal modelsHuntington's diseaseNon-motor symptomsProgressive neurodegenerative disorderDrug therapyDisease progressionPreclinical phaseLoss of functionNeurodegenerative disordersClinical phaseDrug discoveryDiseaseNovel drug discoveryHuntingtin geneToxic gainCAG trinucleotide repeatDrugsProgressionHD geneEnormous progression
2017
Animal Model of Amyotrophic Lateral Sclerosis
Koshal P, Kumar M, Jamwal S, Bansal P. Animal Model of Amyotrophic Lateral Sclerosis. 2017, 277-289. DOI: 10.1007/978-981-10-5981-0_18.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosisMotor neuronsLateral sclerosisMuscle performancePatients of ALSPrevalence of ALSCases of ALSDepletion of neuronsUpper motor neuronsLower motor neuronsFamilial amyotrophic lateral sclerosisInvolvement of neuronsLou Gehrig's diseaseALS-dementiaCerebral cortexMuscle weaknessSubstantia nigraBrain stemDisease progressionSpinal cordMuscle atrophyAnimal modelsAverage ageCognitive impairmentNeurodegenerative disorders
2015
Antidepressants for neuroprotection in Huntington's disease: A review
Jamwal S, Kumar P. Antidepressants for neuroprotection in Huntington's disease: A review. European Journal Of Pharmacology 2015, 769: 33-42. PMID: 26511378, DOI: 10.1016/j.ejphar.2015.10.033.Peer-Reviewed Original ResearchConceptsHuntingtin proteinHuntington's diseaseMAPK/ERK signalingBrain-derived neurotrophic factor (BDNF) productionBDNF/TrkB pathwayProgression of HDDifferent neuroprotective mechanismsPrincipal neuropathological hallmarksUse of antidepressantsNeurotrophic factor productionCortical projection neuronsMutant huntingtin proteinCellular functionsPolyglutamine stretchMolecular mechanismsNH2 terminusERK signalingTrkB pathwayPreclinical evidenceNeuroprotective effectsNeuroprotective mechanismsCommon symptomsProjection neuronsAvailable treatmentsDisease progression