2016
Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats
Sharma N, Jamwal S, Kumar P. Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats. Pathophysiology 2016, 23: 123-134. PMID: 26996500, DOI: 10.1016/j.pathophys.2016.03.002.Peer-Reviewed Original ResearchRotenone administrationCommon age-related neurodegenerative disorderDay one hourPro-inflammatory mediatorsAge-related neurodegenerative disordersLevels of catecholaminesTreatment of PDPathogenesis of PDLevodopa combinationAdjuvant therapyDA neuronsNeuroprotective roleCatecholamine levelsDifferent antidepressantsNeurotransmitter dysfunctionCNS disordersParkinson's diseaseMotor coordinationBody weightAntidepressantsSNpc regionNeurodegenerative disordersParkinsonismBeneficial effectsSertraline
2015
Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats
Kaur N, Jamwal S, Deshmukh R, Gauttam V, Kumar P. Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats. Toxicology Reports 2015, 2: 1222-1232. PMID: 28962465, PMCID: PMC5598492, DOI: 10.1016/j.toxrep.2015.08.004.Peer-Reviewed Original ResearchHuntington's diseaseEthanol extractTreatment of HDBeneficial effectsNon-motor dysfunctionPro-inflammatory mediatorsMedium spiny neuronsExperimental Huntington's diseaseMitochondrial functionRice bran extractBehavioral parametersProphylactic therapyNeurochemical estimationsNeurochemical alterationsProgressive motorPresent studySpiny neuronsAnimal modelsNeurochemical levelsOxidative burdenNeurodegenerative disordersBran extractDiseaseMitochondrial dysfunctionSignificant alterationsPiperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism
Singh S, Jamwal S, Kumar P. Piperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism. Neurochemical Research 2015, 40: 1758-1766. PMID: 26160706, DOI: 10.1007/s11064-015-1658-2.Peer-Reviewed Original ResearchConceptsProtective effectPresence of piperineChronic treatmentMotor deficitsNeuroprotective effectsNeurochemical abnormalitiesAbstract3-Nitropropionic acidPresent studyInduced neurotoxicityMotor functionNeuroprotective activityBody weightMolecular alterationsBeneficial effectsHuntington's diseaseOxidative stressNatural polyphenolNeurotoxicityCurcuminPiperineRatsDiseaseAdministrationBehavioral parametersDaysP3‐324: Beneficial effect of spermidine against 3‐nitropropionic acid‐induced neurotoxicity in rats: Possible neurotransmitter modulation
Kumar P, Jamwal S. P3‐324: Beneficial effect of spermidine against 3‐nitropropionic acid‐induced neurotoxicity in rats: Possible neurotransmitter modulation. Alzheimer's & Dementia 2015, 11: p762-p762. DOI: 10.1016/j.jalz.2015.06.1698.Peer-Reviewed Original ResearchNeurotransmitter modulationBeneficial effects
2014
Mechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders
Rana A, Goyal N, Ahlawat A, Jamwal S, Reddy B, Sharma S. Mechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders. Perfusion 2014, 30: 94-105. PMID: 24947460, DOI: 10.1177/0267659114536760.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideIschemic preconditioningDiabetes mellitusMitochondrial permeability transition poreMito-KATP channelChronic diabetes mellitusGene-related peptideCardio-protective roleIschemia/reperfusionSub-lethal ischemiaGlycogen synthase kinase-3βSynthase kinase-3βCardioprotective effectsMyocardial damageMyocardial infarctionBlood supplyPart of heartMetabolic disordersInvolvement of PTENBeneficial effectsPTEN inhibitorKinase-3βPathological statesMellitusHyperlipidemia