2023
Animal models of Huntington’s disease and their applicability to novel drug discovery and development
Upadhayay S, Jamwal S, Kumar P. Animal models of Huntington’s disease and their applicability to novel drug discovery and development. Expert Opinion On Drug Discovery 2023, 18: 527-538. PMID: 37042034, DOI: 10.1080/17460441.2023.2201493.Peer-Reviewed Original ResearchConceptsHD animal modelsAnimal modelsHuntington's diseaseNon-motor symptomsProgressive neurodegenerative disorderDrug therapyDisease progressionPreclinical phaseLoss of functionNeurodegenerative disordersClinical phaseDrug discoveryDiseaseNovel drug discoveryHuntingtin geneToxic gainCAG trinucleotide repeatDrugsProgressionHD geneEnormous progressionAn Overview of the Pathophysiological Mechanisms of 3-Nitropropionic Acid (3-NPA) as a Neurotoxin in a Huntington's Disease Model and Its Relevance to Drug Discovery and Development
Upadhayay S, Yedke N, Rahi V, Singh S, Kumar S, Arora A, Chandolia P, Kaur P, Kumar M, Koshal P, Jamwal S, Kumar P. An Overview of the Pathophysiological Mechanisms of 3-Nitropropionic Acid (3-NPA) as a Neurotoxin in a Huntington's Disease Model and Its Relevance to Drug Discovery and Development. Neurochemical Research 2023, 48: 1631-1647. PMID: 36738367, DOI: 10.1007/s11064-023-03868-1.Peer-Reviewed Original ResearchConceptsMedium spiny neuronsAnimal modelsGABAergic medium spiny neuronsDisease modelsKey clinical manifestationsHuntington's disease modelsPathogenesis of diseaseWeb of ScienceClinical manifestationsPathophysiological mechanismsSpiny neuronsPreclinical studiesMotor impairmentLike symptomsTherapeutic targetExperimental animalsExcessive productionHuntington's diseaseOxidative stressDiseasePathogenic conditionsDrug discoveryMitochondrial functionFree radicalsNeurotoxin
2021
Pioglitazone transiently stimulates paraoxonase-2 expression in male nonhuman primate brain: Implications for sex-specific therapeutics in neurodegenerative disorders
Blackburn JK, Jamwal S, Wang W, Elsworth JD. Pioglitazone transiently stimulates paraoxonase-2 expression in male nonhuman primate brain: Implications for sex-specific therapeutics in neurodegenerative disorders. Neurochemistry International 2021, 152: 105222. PMID: 34767873, PMCID: PMC8712400, DOI: 10.1016/j.neuint.2021.105222.Peer-Reviewed Original ResearchConceptsPON2 expressionParkinson's diseaseParaoxonase 2Male African green monkeysShort-term animal modelsOxidative stressPeroxisome proliferator-activated receptor gammaEffect of pioglitazoneWeeks of treatmentProliferator-activated receptor gammaNonhuman primate brainParaoxonase-2 expressionRegion-dependent expressionSex-specific therapeuticsAnti-diabetic drug pioglitazoneAfrican green monkeysDorsolateral prefrontal cortexOral pioglitazonePreclinical evidenceSubstantia nigraClinical trialsPON2 mRNAAnimal modelsPioglitazonePrimate brain
2017
Chapter 19 Animal Models of Inflammatory Bowel Disease
Jamwal S, Kumar P. Chapter 19 Animal Models of Inflammatory Bowel Disease. 2017, 467-477. DOI: 10.1016/b978-0-12-809468-6.00019-x.Peer-Reviewed Original ResearchInflammatory bowel diseaseAnimal modelsBowel diseasePathologic mechanismsHuman inflammatory bowel diseaseImmune system overactivationDifferent animal modelsIntestinal inflammationClinical featuresInflammatory conditionsMucosal barrierClinical studiesGut microbiotaSmall intestineCellular alterationsOxidative stressDisease assessmentDiseaseMolecular assessmentAlterationsDate overviewInflammationDrug discoveryPathophysiologyColonAnimal Models of Tardive Dyskinesia
Datta S, Jamwal S, Akula K, Bansal P. Animal Models of Tardive Dyskinesia. 2017, 79-88. DOI: 10.1007/978-981-10-5981-0_6.Peer-Reviewed Original ResearchAnimal Models of Traumatic Brain Injury
Kaur T, Jamwal S, Bansal P. Animal Models of Traumatic Brain Injury. 2017, 89-103. DOI: 10.1007/978-981-10-5981-0_7.Peer-Reviewed Original ResearchTraumatic brain injuryHead injuryBrain injuryPrimary head injurySecondary head injuryBrain contusionNeuronal damageBrain lacerationSecondary injuryPhysical functioningClinical reportsAnimal modelsCell lossInjurySharp objectsMolecular changesDistant tissuesBrainViolent blowConsciousness of personsContusionHospitalizationLacerationPeriod of hoursDamageAnimal Models of Migraine
Jamwal S, Singh S, Bansal P. Animal Models of Migraine. 2017, 105-115. DOI: 10.1007/978-981-10-5981-0_8.Peer-Reviewed Original ResearchAnimal Model of Amyotrophic Lateral Sclerosis
Koshal P, Kumar M, Jamwal S, Bansal P. Animal Model of Amyotrophic Lateral Sclerosis. 2017, 277-289. DOI: 10.1007/978-981-10-5981-0_18.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosisMotor neuronsLateral sclerosisMuscle performancePatients of ALSPrevalence of ALSCases of ALSDepletion of neuronsUpper motor neuronsLower motor neuronsFamilial amyotrophic lateral sclerosisInvolvement of neuronsLou Gehrig's diseaseALS-dementiaCerebral cortexMuscle weaknessSubstantia nigraBrain stemDisease progressionSpinal cordMuscle atrophyAnimal modelsAverage ageCognitive impairmentNeurodegenerative disordersAnimal Models of Epilepsy
Koshal P, Jamwal S, Akula K, Bansal P. Animal Models of Epilepsy. 2017, 59-78. DOI: 10.1007/978-981-10-5981-0_5.Peer-Reviewed Original ResearchCentral nervous systemAntiepileptic drugsEpileptic seizuresPrinciple inhibitory neurotransmitterDevelopment of epilepsyLong-term outcomesType of epilepsyExcessive electrical dischargesGABAergic axon terminalsTreatment of epilepsyCommon neurological disorderPopulations of neuronsAmino butyric acidFrequent seizuresGABAB receptorsSecondary complicationsInhibitory neurotransmitterGABAA receptorsMotor disordersAxon terminalsEpileptic patientsHealthcare costsAnimal modelsNervous systemNeonatal stageAnimal Model of Anxiety
Bansal P, Singh S, Jamwal S. Animal Model of Anxiety. 2017, 139-158. DOI: 10.1007/978-981-10-5981-0_10.Peer-Reviewed Original ResearchEveryday life situationsGeneralized anxiety disorderAnxiety disordersUnrealistic worryPanic disorderAutonomic nervous system arousalLife situationsHuman anxiety disordersPsychological treatmentAnxiety-related behaviorPathological anxietyIntense fearExtreme fearAnxietyBehavioral disturbancesPanic attacksPainful stimuliFearWorryDisordersAnimal modelsArousalSymptomologyStimuliPrimary symptomsAnimal Models of Attention-Deficit Hyperkinetic Disorder (ADHD)
Sharma N, Jamwal S, Bansal P. Animal Models of Attention-Deficit Hyperkinetic Disorder (ADHD). 2017, 217-232. DOI: 10.1007/978-981-10-5981-0_14.Peer-Reviewed Original ResearchAttention deficit hyperkinetic disorderAttention deficit disorderHyperactivity disorderDeficit disorderAttention deficit hyperactivity disorderDeficit hyperactivity disorderCommon childhood-onset neuropsychiatric disorderSchool-aged childrenADHD childrenAttention deficitsChildhood-onset neuropsychiatric disorderChildhood disordersBehavioral disordersSigns of hyperactivityHyperkinetic disorderHyperactivityChildrenTerms of choiceBrain damageNeuropsychiatric disordersDSM-IIIDisordersAdultsInattentionAnimal modelsBehavioral Tests for Rodent Models
Jamwal S, Singh S, Bansal P. Behavioral Tests for Rodent Models. 2017, 315-341. DOI: 10.1007/978-981-10-5981-0_21.Peer-Reviewed Original ResearchMotor coordinationPerformance-based testsTraumatic brain injuryBrain injuryBehavioral testsTesting of drugsMotor activityRotating rodRotarod testGrip strengthMovement disordersRodent modelsAnimal modelsExperimental drugsPreclinical researchDrugsDisordersRodentsTestLatencyResearchRotarodInjuryCoordination
2015
Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats
Kaur N, Jamwal S, Deshmukh R, Gauttam V, Kumar P. Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats. Toxicology Reports 2015, 2: 1222-1232. PMID: 28962465, PMCID: PMC5598492, DOI: 10.1016/j.toxrep.2015.08.004.Peer-Reviewed Original ResearchHuntington's diseaseEthanol extractTreatment of HDBeneficial effectsNon-motor dysfunctionPro-inflammatory mediatorsMedium spiny neuronsExperimental Huntington's diseaseMitochondrial functionRice bran extractBehavioral parametersProphylactic therapyNeurochemical estimationsNeurochemical alterationsProgressive motorPresent studySpiny neuronsAnimal modelsNeurochemical levelsOxidative burdenNeurodegenerative disordersBran extractDiseaseMitochondrial dysfunctionSignificant alterations