2014
Paroxysmal itch caused by gain-of-function Nav1.7 mutation
Devigili G, Eleopra R, Pierro T, Lombardi R, Rinaldo S, Lettieri C, Faber C, Merkies I, Waxman S, Lauria G. Paroxysmal itch caused by gain-of-function Nav1.7 mutation. Pain 2014, 155: 1702-1707. PMID: 24820863, DOI: 10.1016/j.pain.2014.05.006.Peer-Reviewed Original ResearchConceptsIntraepidermal nerve fiber densityNerve fiber densityFiber densityAutonomic cardiovascular reflexesFunction Nav1.7 mutationsNerve conduction studiesManifestations of allergyQuantitative sensory testingParadoxical heat sensationProfile assessmentConsequence of diseaseNav1.7 sodium channelCardiovascular reflexesPregabalin treatmentAutonomic testsConduction studiesNav1.7 mutationPain thresholdClinical pictureSystemic diseaseSomatosensory pathwaysSkin biopsiesIndex patientsSensory testingSpicy foods
2005
Chapter 20 New Molecular Targets for the Treatment of Neuropathic Pain
Wood J, Waxman S. Chapter 20 New Molecular Targets for the Treatment of Neuropathic Pain. 2005, 339-355. DOI: 10.1016/b978-012738903-5/50021-7.Peer-Reviewed Original ResearchNeuropathic painPeripheral nervous system degenerationGene regulation studiesMolecular targetsAnimal modelsInteresting drug targetGene expressionRegulatory moleculesNew molecular targetsMolecular mechanismsEffective drug developmentNervous system degenerationTransgenic animalsUseful animal modelRegulation studiesDrug targetsGene ablationEfficacy of drugsConsequence of diseaseHerpes zosterImmunodeficiency syndromeRecent insightsPeripheral nervesSystem degenerationPain