2016
Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia
Onorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell’Anno M, Gulden FO, Pochareddy S, Tebbenkamp AT, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N. Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell Reports 2016, 16: 2576-2592. PMID: 27568284, PMCID: PMC5135012, DOI: 10.1016/j.celrep.2016.08.038.Peer-Reviewed Original ResearchMeSH KeywordsAxl Receptor Tyrosine KinaseBrainCell DeathCentrosomeFetusGene Expression ProfilingHumansImmunity, InnateMicrocephalyMitochondriaMitosisNeocortexNeural Stem CellsNeuroepithelial CellsNeurogliaNeuronsNeuroprotective AgentsNucleosidesPhosphorylationProtein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesSpinal CordTranscription, GeneticVirus ReplicationZika VirusZika Virus InfectionConceptsRadial glial cellsNES cellsNeuroepithelial stem cellsZIKV infectionFetal brain slicesStem cellsEarly human neurodevelopmentHuman neuroepithelial stem cellsHuman neural stem cellsCell deathSingle-cell RNA-seqNeural stem cellsNeurodevelopment defectsZIKV replicationGlial cellsBrain slicesPotential treatmentRadial gliaZika virusPhospho-TBK1Neurodevelopmental defectsRNA-seqSupernumerary centrosomesNucleoside analoguesHuman neurodevelopment
1999
Go protein-dependent survival of primary accessory olfactory neurons
Tanaka M, Treloar H, Kalb R, Greer C, Strittmatter S. Go protein-dependent survival of primary accessory olfactory neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 14106-14111. PMID: 10570206, PMCID: PMC24198, DOI: 10.1073/pnas.96.24.14106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell Adhesion Molecules, NeuronalCell SurvivalCells, CulturedFemaleGTP-Binding Protein alpha Subunit, Gi2GTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gi-GoHeterotrimeric GTP-Binding ProteinsHumansMaleMiceMice, Inbred C57BLMice, KnockoutNeural Cell Adhesion MoleculesNeuronsProto-Oncogene ProteinsProto-Oncogene Proteins c-fosRatsSynaptophysinVomeronasal OrganConceptsPosterior accessory olfactory bulbCell survivalAccessory olfactory bulbG proteinsOlfactory systemAccessory olfactory systemG protein-independent processReceptor-coupled G proteinsG protein-coupled receptor familyProtein-coupled receptor familyVNO neuronsAxonal targetingSensory functionAxonal guidanceReceptor familyAnterior accessory olfactory bulbTargeted deletionOlfactory neuronsReceptor neuronsC-Fos immunoreactivityProteinApoptotic neuronsNeurons decreasesOlfactory bulbSensory activation