2021
NogoA-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in primates
Boghdadi AG, Spurrier J, Teo L, Li M, Skarica M, Cao B, Kwan WC, Merson TD, Nilsson SK, Sestan N, Strittmatter SM, Bourne JA. NogoA-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in primates. Nature Communications 2021, 12: 6906. PMID: 34824275, PMCID: PMC8617297, DOI: 10.1038/s41467-021-27245-0.Peer-Reviewed Original ResearchConceptsBrain injuryPeripheral macrophage infiltrationIschemic brain injuryAnti-inflammatory responseMajority of astrocytesNeurite outgrowth inhibitory proteinIschemic strokePeripheral macrophagesReactive astrocytesMacrophage infiltrationStroke recoveryAstrocyte clustersMarmoset monkeysVisual cortexAstrocytesNogoASingle-nucleus transcriptomicsInhibitory proteinInjuryStrokeHuman brainInfiltrationCritical rolePrecise functionOligodendrocytes
2004
Regulating axon growth within the postnatal central nervous system
Hu F, Strittmatter SM. Regulating axon growth within the postnatal central nervous system. Seminars In Perinatology 2004, 28: 371-378. PMID: 15693393, DOI: 10.1053/j.semperi.2004.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCentral Nervous SystemGPI-Linked ProteinsGrowth InhibitorsHumansHypoxiaIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinNerve RegenerationNerve Tissue ProteinsNogo ProteinsNogo Receptor 1Receptor, Nerve Growth FactorReceptors, Cell SurfaceConceptsCentral nervous systemAxonal growthNervous systemNeuronal developmentAdult central nervous systemMature central nervous systemAxon growth inhibitorsPostnatal central nervous systemPotential therapeutic interventionsNew neuronal connectionsMyelin-derived proteinsAxonal sproutingDirect blockadeNgR proteinPostnatal brainNeuronal connectionsTherapeutic interventionsAxon growthDevelopmental hypoxiaReduced expressionMyelin proteinsHypoxic conditionsInhibitor pathwayImportant investigationCritical role