2008
Nogo-66 Receptor Antagonist Peptide (NEP1-40) Administration Promotes Functional Recovery and Axonal Growth After Lateral Funiculus Injury in the Adult Rat
Cao Y, Shumsky JS, Sabol MA, Kushner RA, Strittmatter S, Hamers FP, Lee DH, Rabacchi SA, Murray M. Nogo-66 Receptor Antagonist Peptide (NEP1-40) Administration Promotes Functional Recovery and Axonal Growth After Lateral Funiculus Injury in the Adult Rat. Neurorehabilitation And Neural Repair 2008, 22: 262-278. PMID: 18056009, PMCID: PMC2853251, DOI: 10.1177/1545968307308550.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalDenervationEfferent PathwaysFemaleGPI-Linked ProteinsGrowth ConesMyelin ProteinsNerve RegenerationNeuronal PlasticityNogo Receptor 1Peptide FragmentsPyramidal TractsRaphe NucleiRatsRats, Sprague-DawleyReceptors, Cell SurfaceRecovery of FunctionRed NucleusSpinal Cord InjuriesSpinal Nerve RootsTreatment OutcomeWallerian DegenerationConceptsNEP1-40 groupDorsal root axonsRST axonsRubrospinal axonsRubrospinal tractAxonal growthNEP1-40 treatmentPromotes Functional RecoveryCervical spinal cordDorsal hemisectionForelimb usageNEP1-40Corticospinal axonsFunctional recoveryIntrathecal deliveryLateral funiculusSpinal cordMotor functionOutcome measuresAdult ratsLesion siteOperated controlsWhite matterGait analysisAxons
2003
Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS
Fournier AE, Takizawa BT, Strittmatter SM. Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS. Journal Of Neuroscience 2003, 23: 1416-1423. PMID: 12598630, PMCID: PMC6742251, DOI: 10.1523/jneurosci.23-04-01416.2003.Peer-Reviewed Original ResearchMeSH KeywordsADP Ribose TransferasesAmidesAnimalsAxonsBotulinum ToxinsCells, CulturedChick EmbryoEnzyme InhibitorsFemaleGanglia, SpinalIntracellular Signaling Peptides and ProteinsMotor ActivityMyelin ProteinsNerve RegenerationNeuritesNogo ProteinsPC12 CellsProtein Serine-Threonine KinasesPyridinesRatsRats, Sprague-DawleyRho GTP-Binding ProteinsRho-Associated KinasesSpinal Cord InjuriesConceptsAxonal regenerationAdult ratsNeurite outgrowthCorticospinal tract lesionsNeurite outgrowth inhibitorChick DRG neuronsRho-kinase inhibitionCST fibersDRG neuronsCST lesionLocomotor recoveryTract lesionsSpinal cordOutgrowth inhibitorInhibits neurite outgrowthNogo-66Activity levelsMyelinKinase inhibitionLesionsActivation of RhoRatsC3 transferaseInhibition of p160ROCKInhibitors
1986
Differential ontogeny of rat brain peptidases: prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme.
Strittmatter SM, Lynch DR, Snyder SH. Differential ontogeny of rat brain peptidases: prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme. Brain Research 1986, 394: 207-15. PMID: 3021286, DOI: 10.1016/0165-3806(86)90096-9.Peer-Reviewed Original ResearchConceptsBasal gangliaAdult ratsChoroid plexusEnkephalin convertaseAdult levelsRat brain peptidasesExpression of ACEWeeks of ageBrain peptidasesStriatonigral systemAcid autoradiographyPerinatal periodPostnatal weekRat brainDifferential ontogenyPostnatal developmentPrenatal expressionMost neuropeptidesAngiotensinHigh concentrationsThalamusGangliaBirthPlexusRatsDifferential ontogeny of rat brain peptidases: Prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme
Strittmatter S, Lynch D, Snyder S. Differential ontogeny of rat brain peptidases: Prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme. Brain Research 1986, 29: 207-215. DOI: 10.1016/0165-3806(86)90096-9.Peer-Reviewed Original ResearchBasal gangliaAdult ratsChoroid plexusEnkephalin convertaseAdult levelsRat brain peptidasesExpression of ACEWeeks of ageBrain peptidasesStriatonigral systemAcid autoradiographyPerinatal periodPostnatal weekRat brainDifferential ontogenyPostnatal developmentPrenatal expressionMost neuropeptidesAngiotensinHigh concentrationsThalamusGangliaBirthPlexusRats