Stephanie Thorn, MSc, PhD

Assistant Professor of Medicine (Cardiovascular Medicine)

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Appointments

Cardiovascular Medicine

Primary

Comparative Medicine

Secondary

Additional Titles

Associate Director, Yale Translational Research Imaging Center (Y-TRIC)

Contact Info

203.737.5917

Yale School of Medicine

PO Box 208017, DANA 3

New Haven, CT 06520-8017

United States

About

Titles

Assistant Professor of Medicine (Cardiovascular Medicine)

Associate Director, Yale Translational Research Imaging Center (Y-TRIC)

Biography

Dr Stephanie L. Thorn, MSc, PhD is an Assistant Professor in the Section of Cardiovascular Medicine, Department of Internal Medicine. Dr Thorn received her PhD at the University of Ottawa Heart Institute in Cellular and Molecular Medicine. She is currently the Associate Director of the Yale Translational Research Imaging Center (YTRIC). Her research interests are centered on cardiovascular imaging, using PET, SPECT and CT to develop new approaches in the interrogation of molecular pathways, quantification of blood flow and alterations in myocardial function. Dr Thorn specifically pursues translational research in ischemia-reperfusion remodeling, myocardial infarction and right ventricular heart failure.

Appointments

Cardiovascular Medicine
Assistant Professor
Primary
Cardiovascular Medicine
Comparative Medicine
Research Scientist
Secondary
Comparative Medicine

Cardiovascular Medicine
Comparative Medicine
Internal Medicine
Yale Biomedical Imaging Institute
Yale Translational Research Imaging Center (Y-TRIC)

Education & Training

PhD: University of Ottawa, Cellular and Molecular Medicine (2013)

MSc: University of Guelph, Human Biology and Nutritional Sciences (2003)

BSc (Hon): University of Guelph, Human Kinetics (2001)

Research

Overview

Medical Research Interests

Computed Tomography Angiography; Diseases; Heart Failure; Heart Failure, Diastolic; Hypertrophy, Right Ventricular; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Positron Emission Tomography Computed Tomography; Radionuclide Imaging; Single Photon Emission Computed Tomography Computed Tomography

ORCID
0000-0003-0020-0814
YTRIC
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Research at a Glance

Yale Co-Authors

Frequent collaborators of Stephanie Thorn's published research.

Albert Sinusas, MD
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View 24 Common Publications
Chi Liu, PhD
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View 9 Common Publications
Alaa Alashi, MD, MHS
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Edward J Miller, MD
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Santiago Callegari, MD
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Yi-Hwa Liu, PhD
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Publications

2025

Increasing angular sampling for dedicated cardiac SPECT scanner: Implementation with Deep Learning and Validation with human data
Xie H, Alashi A, Thorn S, Chen X, Zhou B, Sinusas A, Liu C. Increasing angular sampling for dedicated cardiac SPECT scanner: Implementation with Deep Learning and Validation with human data. Journal Of Nuclear Cardiology 2025, 102168. PMID: 39986346, DOI: 10.1016/j.nuclcard.2025.102168.
Peer-Reviewed Original Research
Concepts
Lower Extremity Flow Quantification Using Dynamic 82Rb PET: a Preclinical Investigation
Guo L, Thorn S, de Rubio Cruz P, Liu Z, Gallezot J, Liu Q, Moulton E, Carson R, Sinusas A, Liu C. Lower Extremity Flow Quantification Using Dynamic 82Rb PET: a Preclinical Investigation. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, PP: 1-1. DOI: 10.1109/trpms.2025.3542729.
Peer-Reviewed Original Research
Concepts
Imaging Fibroblast Activation Protein Direct Visualization of Matrix Proteolytic Activity in Patients Post Myocardial Infarction
Thorn S, Spinale F, Sinusas A. Imaging Fibroblast Activation Protein Direct Visualization of Matrix Proteolytic Activity in Patients Post Myocardial Infarction. Journal Of The American College Of Cardiology 2025, 85: 592-594. PMID: 39772365, DOI: 10.1016/j.jacc.2024.11.029.
Peer-Reviewed Original Research

2024

New Horizons in Nuclear Cardiology: Imaging of Peripheral Arterial Disease
Callegari S, Mena-Hurtado C, Smolderen K, Thorn S, Sinusas A. New Horizons in Nuclear Cardiology: Imaging of Peripheral Arterial Disease. Journal Of Nuclear Cardiology 2024, 102079. PMID: 39549830, DOI: 10.1016/j.nuclcard.2024.102079.
Peer-Reviewed Original Research
Concepts
Coordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging
Jeng G, Chen P, Hsieh M, Liu Z, Langdon J, Ahn S, Staib L, Stendahl J, Thorn S, Sinusas A, Duncan J, O'Donnell M. Coordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging. IEEE Transactions On Biomedical Engineering 2024, 71: 3312-3323. PMID: 38941195, PMCID: PMC11637688, DOI: 10.1109/tbme.2024.3420220.
Peer-Reviewed Original Research
Concepts
Molecular Imaging of Fibroblast Activation in Lower Extremity Skeletal Muscles Using a 99mTc-Labeled Inhibitor of Fibroblast Activation Protein in Porcine Model of Peripheral Artery Disease
Jang S, Thorn S, Zohora F, Porcaro O, Burns R, Vermillion B, Callegari S, Guerrera N, DePino A, Liu C, Luna-Gutierrez M, Ferro-Flores G, Sinusas A. Molecular Imaging of Fibroblast Activation in Lower Extremity Skeletal Muscles Using a 99mTc-Labeled Inhibitor of Fibroblast Activation Protein in Porcine Model of Peripheral Artery Disease. Journal Of Nuclear Cardiology 2024, 38: 101997. DOI: 10.1016/j.nuclcard.2024.101997.
Peer-Reviewed Original Research
Hybrid SPECT/CT Imaging of Fibroblast Activation Protein Post Myocardial Infarction on Novel 360° CZT Scanner
Thorn S, Burns R, Zohora F, Jang S, Porcaro O, Guerrera N, DePino A, Vermillion B, Liu C, Luna-Gutiérrez M, Ferro-Flores G, Sinusas A. Hybrid SPECT/CT Imaging of Fibroblast Activation Protein Post Myocardial Infarction on Novel 360° CZT Scanner. Journal Of Nuclear Cardiology 2024, 38: 101972. DOI: 10.1016/j.nuclcard.2024.101972.
Peer-Reviewed Original Research
Development Of Ct Quantitative Tools To Assess Collateral Formation In Rabbit Model Of Hind Limb Ischemia: Implications For Evaluation Of Vascular Reserve.
Vermillion B, Jang S, Alashi A, Burns R, Guerrera N, Depino A, Martins S, Papademetris X, Zeiss C, Guo L, Liu C, Thorn S, Sinusas A. Development Of Ct Quantitative Tools To Assess Collateral Formation In Rabbit Model Of Hind Limb Ischemia: Implications For Evaluation Of Vascular Reserve. Journal Of Cardiovascular Computed Tomography 2024, 18: s50-s51. DOI: 10.1016/j.jcct.2024.05.117.
Peer-Reviewed Original Research
Non-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome
Jang S, Thorn S, Vermillion B, Alashi A, Zohora F, Lee S, Ahn S, Burns R, Dela Cruz C, Zeiss C, Spinale F, Heerdt P, Sinusas A. Non-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome. Journal Of Cardiovascular Computed Tomography 2024, 18: s46. DOI: 10.1016/j.jcct.2024.05.106.
Peer-Reviewed Original Research
Concepts
Early Transient CT Enhancement Post Myocardial Infarction Is Associated With Technetium-99m Pyrophosphate Uptake And Calcium Deposition
Zohora F, Lee S, Lin A, Jang S, Vermillion B, Burns R, Callegari S, DePino A, Guerrera N, Thorn S, Sinusas A. Early Transient CT Enhancement Post Myocardial Infarction Is Associated With Technetium-99m Pyrophosphate Uptake And Calcium Deposition. Journal Of Cardiovascular Computed Tomography 2024, 18: s25-s26. DOI: 10.1016/j.jcct.2024.05.058.
Peer-Reviewed Original Research

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Academic Achievements & Community Involvement

Activities

activity
Hotspot Imaging in Cardiovascular Disease: Methodology of Image Acquisition and Tracer Quantification
06/27/2023 - 06/27/2023Oral PresentationSociety of Nuclear Medicine and Molecular Imaging Annual Meeting
Details

News & Links

Media

Contrast CT images of a normal myocardium and one with right ventricle heart failure.
Using non-invasive SPECT/CT hybrid imaging, the reduced perfusion area can be quantified. At 3-days post-ischemia, the same area shows an increase in the radiotracer uptake of the matrix metalloproteinase agent, Tc-99m RP805. This tracer is an index of cardiac remodeling.

News

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Contacts

Academic Office Number

203.737.5917

Lab Number

203.785.5005

Mailing Address

Yale School of Medicine

PO Box 208017, DANA 3

New Haven, CT 06520-8017

United States

Appointments

Additional Titles

Contact Info

Titles

Biography

Appointments

Cardiovascular Medicine

Comparative Medicine

Other Departments & Organizations

Education & Training

Overview

Medical Research Interests

ORCID

YTRIC

Research at a Glance

Yale Co-Authors

Albert Sinusas, MD

Chi Liu, PhD

Alaa Alashi, MD, MHS

Edward J Miller, MD

Santiago Callegari, MD

Yi-Hwa Liu, PhD

Publications

2025

2024

Activities

Hotspot Imaging in Cardiovascular Disease: Methodology of Image Acquisition and Tracer Quantification

Media

Right Ventricle Heart Failure

Cardiac Ischemia-Reperfusion

News

Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions

Meet Yale Internal Medicine: Stephanie Thorn, MSc, PhD

Yale's Cardiac Imaging Center Revolutionizes Translational Research

Image-guided Therapy Improves Cardiac Function Post-MI (Discoveries & Impact July 2023)

Contacts