Increased levels of interleukin-10 and transforming growth factor-β in the plasma and ascitic fluid of patients with advanced ovarian cancer
Santin A, Bellone S, Ravaggi A, Roman J, Smith C, Pecorelli S, Cannon M, Parham G. Increased levels of interleukin-10 and transforming growth factor-β in the plasma and ascitic fluid of patients with advanced ovarian cancer. BJOG An International Journal Of Obstetrics & Gynaecology 2001, 108: 804-808. DOI: 10.1016/s0306-5456(00)00206-0.Peer-Reviewed Original ResearchOvarian cancer patientsAdvanced ovarian cancerIL-10Cancer patientsOvarian cancerAscitic fluidPlasma levelsPeritoneal fluidAdvanced ovarian cancer patientsElevated TGF-β levelsImmunosuppressive cytokine IL-10Anti-tumor immune functionDetectable IL-10Cytokine IL-10TGF-β levelsTime of surgeryDepartment of ObstetricsPlasma samplesNormal female controlsSensitive enzyme-linked immunosorbentEnzyme-linked immunosorbentTGF-β releaseImmunosuppressive cytokinesInterleukin-10Normal control plasma samples