2015
A single-nucleotide-polymorphism real-time PCR assay for genotyping of Mycobacterium tuberculosis complex in peri-urban Kampala
Wampande EM, Hatzios SK, Achan B, Mupere E, Nsereko M, Mayanja HK, Eisenach K, Boom WH, Gagneux S, Joloba ML, For the Tuberculosis Research Unit. A single-nucleotide-polymorphism real-time PCR assay for genotyping of Mycobacterium tuberculosis complex in peri-urban Kampala. BMC Infectious Diseases 2015, 15: 396. PMID: 26423522, PMCID: PMC4590274, DOI: 10.1186/s12879-015-1121-7.Peer-Reviewed Original ResearchConceptsMycobacterium tuberculosis complexSputum samplesTB patientsReal-time PCRSingle nucleotide polymorphismsLineage-specific single nucleotide polymorphismsSmear-positive sputum samplesMTBC strainsTuberculosis complexLineage 4Pathogenesis of tuberculosisMTBC lineagesLineage 3Indeterminate lineagePeri-urban KampalaLineages/sublineagesMTBC isolatesHigh-throughput genotypingTargeted sequencingPatientsHigh-throughput techniquesTuberculosisFurther validationRoutine genotypingNucleotide polymorphisms
2011
The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis
Hatzios SK, Bertozzi CR. The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis. PLOS Pathogens 2011, 7: e1002036. PMID: 21811406, PMCID: PMC3141025, DOI: 10.1371/journal.ppat.1002036.Peer-Reviewed Original ResearchConceptsSulfate assimilation pathwayAssimilation pathwayDiverse environmental cuesMycobacterium tuberculosisBiosynthesis of moleculesHost immune cellsSmall molecule regulatorsSuccessful human pathogenSulfur metabolismRegulatory cuesMtb infectionGranuloma formationImmune cellsEnvironmental cuesRegulatory proteinsSulfur-containing metabolitesMolecule regulatorsAlveolar macrophagesTherapeutic interventionsMetabolism regulationBiochemical mechanismsIntracellular pathogensMetabolic adaptationHuman pathogensTuberculosis