Sourav Ghosh, PhD

Sourav Ghosh, Ph.D. obtained a M.Sc. in Zoology at the University of Calcutta, where he studied Drosophila and mosquito genetics. Next, he completed his graduate studies on cell cytoskeleton and protein trafficking under the direction of John V. Cox at the University of Tennessee, Memphis. Subsequently, Dr. Ghosh did his postdoctoral research on cell signaling at the Salk Institute for Biological Studies under the guidance of Tony Hunter. In 2007, Dr. Ghosh joined University of Arizona as an Assistant Professor, and in 2014 he moved to Yale University School of Medicine. Dr. Ghosh and Dr. Carla Rothlin co-direct a lab studying the regulation of inflammation (Rothin, Ghosh et al. Cell, 2007, Carrera Silva et al. Immunity, 2013, Bosurgi et al. Science, 2017). While inflammation is a cardinal feature for immune defense, the magnitude and period of the inflammatory response has to follow the ‘Goldilocks Principle’ wherein inflammation would be detrimental if its amplitude is too little or too much, or its period too short or too long. Drs. Rothlin and Ghosh investigates the principles and molecular mechanisms that negatively regulate inflammation and ensure that the amplitude and period of inflammation is ‘just right’. Defects in these molecular circuits can manifest as wide ranging clinical problems including chronic or pathological inflammation, autoimmunity and pathological wound healing, while harnessing these checkpoints can improve anti-cancer immunity.