2021
Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development
Xia S, VanKuren NW, Chen C, Zhang L, Kemkemer C, Shao Y, Jia H, Lee U, Advani AS, Gschwend A, Vibranovski MD, Chen S, Zhang YE, Long M. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. PLOS Genetics 2021, 17: e1009654. PMID: 34242211, PMCID: PMC8270118, DOI: 10.1371/journal.pgen.1009654.Peer-Reviewed Original ResearchConceptsNew genesPhenotypic effectsEssential functionsLong evolutionary time scalesDevelopment of DrosophilaEvolutionary time scalesDrosophila developmentDrosophila genusEssential genesGene essentialityRNAi libraryYoung genesGenomic analysisCRISPR knockoutKnockout approachGenetic basisKnockdown experimentsComputational identificationGene effectsGenesDuplicate copiesRapid evolutionDrosophilaKnockdown efficiencyDistant ancestors
2010
New Genes in Drosophila Quickly Become Essential
Chen S, Zhang YE, Long M. New Genes in Drosophila Quickly Become Essential. Science 2010, 330: 1682-1685. PMID: 21164016, PMCID: PMC7211344, DOI: 10.1126/science.1196380.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsBody PatterningDrosophilaDrosophila melanogasterDrosophila ProteinsEvolution, MolecularGene DuplicationGene Expression ProfilingGene Expression Regulation, DevelopmentalGenes, EssentialGenes, InsectLarvaMetamorphosis, BiologicalPhenotypePhylogenyPupaRNA InterferenceTime FactorsWings, Animal