2023
Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System
Zhang L, Park J, Dong M, Arsala D, Xia S, Chen J, Sosa D, Atlas J, Long M, Chen S. Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System. Genome Biology And Evolution 2023, 15: evad081. PMID: 37170918, PMCID: PMC10210621, DOI: 10.1093/gbe/evad081.Peer-Reviewed Original ResearchT cell adaptive immunityNew genesPositive selectionRapid gene duplicationEvolution of longevityStrong positive selectionVertebrate immune systemAdaptive immunityAmino acid substitutionsVertebrate lineageGene ageGene duplicationEutherian radiationGene annotationGenome assemblyRapid originationVertebrate speciesPlacental mammalsHuman genesImmunity genesMolecular adaptationsNucleotide sequenceGenetic constructionNegative regulatorInteraction pathway
2003
RNA-dependent RNA polymerase gene sequence from foot-and-mouth disease virus in Hong Kong
Chen X, Feng Q, Wu Z, Liu Y, Huang K, Shi R, Chen S, Lu W, Ding M, Collins R, Fung Y, Lau L, Yu A, Chen J. RNA-dependent RNA polymerase gene sequence from foot-and-mouth disease virus in Hong Kong. Biochemical And Biophysical Research Communications 2003, 308: 899-905. PMID: 12927804, DOI: 10.1016/s0006-291x(03)01511-0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceBase SequenceCloning, MolecularConserved SequenceDNA-Directed RNA PolymerasesFoot-and-Mouth Disease VirusGenetic VariationHong KongModels, GeneticMolecular Sequence DataMutationPhylogenyProtein Structure, TertiaryReverse Transcriptase Polymerase Chain ReactionRNA, ViralRNA-Dependent RNA PolymeraseSequence Analysis, DNASequence Homology, Amino AcidConceptsRNA-dependent RNA polymerase gene sequencesNucleotide sequenceRNA polymerase gene sequencesViral RNA-dependent RNA polymeraseRNA-dependent RNA polymeraseAmino acid sequenceAmino acid residuesMouth disease virusPolymerase gene sequencesCommon ancestorEvolutionary treeRNA polymeraseGene sequencesSequence comparisonAcid sequenceSame geneN-terminusDisease virusAcid residuesGenesFunctional relevanceRepresentative isolatesHost immune systemFMDV isolatesHKN/2002