Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System
Zhang L, Park J, Dong M, Arsala D, Xia S, Chen J, Sosa D, Atlas J, Long M, Chen S. Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System. Genome Biology And Evolution 2023, 15: evad081. PMID: 37170918, PMCID: PMC10210621, DOI: 10.1093/gbe/evad081.Peer-Reviewed Original ResearchT cell adaptive immunityNew genesPositive selectionRapid gene duplicationEvolution of longevityStrong positive selectionVertebrate immune systemAdaptive immunityAmino acid substitutionsVertebrate lineageGene ageGene duplicationEutherian radiationGene annotationGenome assemblyRapid originationVertebrate speciesPlacental mammalsHuman genesImmunity genesMolecular adaptationsNucleotide sequenceGenetic constructionNegative regulatorInteraction pathway