2022
Synaptotagmin rings as high-sensitivity regulators of synaptic vesicle docking and fusion
Zhu J, McDargh ZA, Li F, Krishnakumar SS, Rothman JE, O’Shaughnessy B. Synaptotagmin rings as high-sensitivity regulators of synaptic vesicle docking and fusion. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2208337119. PMID: 36103579, PMCID: PMC9499556, DOI: 10.1073/pnas.2208337119.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateCalciumPhosphatidylinositol 4,5-DiphosphateSynaptic VesiclesSynaptotagmin IConceptsVesicle dockingPlasma membrane domainsSynaptic vesiclesCalcium sensor synaptotagminSynaptic vesicle dockingInhibitor of fusionFusion clampSensor synaptotagminMembrane domainsTrigger fusionPlasma membraneC2AB domainAnionic phospholipid bilayersNeuronal synapsesMembrane compositionPhospholipid monolayersATP levelsVesiclesExocytotic releaseDockingPhospholipid bilayers
2017
Circular oligomerization is an intrinsic property of synaptotagmin
Wang J, Li F, Bello OD, Sindelar CV, Pincet F, Krishnakumar SS, Rothman JE. Circular oligomerization is an intrinsic property of synaptotagmin. ELife 2017, 6: e27441. PMID: 28850328, PMCID: PMC5576491, DOI: 10.7554/elife.27441.Peer-Reviewed Original Research
2016
Using ApoE Nanolipoprotein Particles To Analyze SNARE-Induced Fusion Pores
Bello OD, Auclair SM, Rothman JE, Krishnakumar SS. Using ApoE Nanolipoprotein Particles To Analyze SNARE-Induced Fusion Pores. Langmuir 2016, 32: 3015-3023. PMID: 26972604, PMCID: PMC4946868, DOI: 10.1021/acs.langmuir.6b00245.Peer-Reviewed Original ResearchMeSH KeywordsApolipoproteins ECalciumCholesterolDextransDimyristoylphosphatidylcholineDithioniteFluorescent DyesLiposomesMembrane FusionNanoparticlesParticle SizePhosphatidylcholinesPhosphatidylethanolaminesPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositolsPhosphatidylserinesSynaptosomal-Associated Protein 25Syntaxin 1Vesicle-Associated Membrane Protein 2