2023
A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope
Lee S, Rodrı́guez J, Merta H, Bahmanyar S. A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope. Journal Of Cell Biology 2023, 222: e202304026. PMID: 37382667, PMCID: PMC10309186, DOI: 10.1083/jcb.202304026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsLipid MetabolismMembrane ProteinsMembranesNuclear EnvelopePhosphoprotein PhosphatasesProteolysisConceptsAmphipathic helixDirect lipid-protein interactionsNuclear envelopeLipid-protein interactionsLipid compositionPhosphatidic acid phosphatase lipin-1INM proteomeNucleoplasmic domainOrganelle identityProteasomal regulationMembrane domainsAnimal cellsProteasomal degradationMaster regulatorProtein degradationLipid environmentLipin-1Packing defectsDAG speciesCTDNEP1Metabolism impactsSUN2Disease mechanismsMetabolismBroad implications
2020
Lipid and protein dynamics that shape nuclear envelope identity
Bahmanyar S, Schlieker C. Lipid and protein dynamics that shape nuclear envelope identity. Molecular Biology Of The Cell 2020, 31: 1315-1323. PMID: 32530796, PMCID: PMC7353140, DOI: 10.1091/mbc.e18-10-0636.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CycleHumansLipid BilayersLipid MetabolismMembrane FusionMitosisNuclear EnvelopeConceptsNuclear envelopeEndoplasmic reticulumMembrane fusionNuclear pore complex biogenesisUnique protein compositionBulk endoplasmic reticulumDe novo lipid synthesisNPC biogenesisComplex biogenesisNovo lipid synthesisLipid asymmetryProtein dynamicsProtein compositionElusive mechanismLipid synthesisLipid bilayersBiogenesisPermeability barrierFunctional specializationMajor threatLipid metabolismUnique compositionMitosisReticulumCompartmentalization
2018
The Inner Nuclear Membrane Takes On Lipid Metabolism
Merta H, Bahmanyar S. The Inner Nuclear Membrane Takes On Lipid Metabolism. Developmental Cell 2018, 47: 397-399. PMID: 30458132, DOI: 10.1016/j.devcel.2018.11.005.Peer-Reviewed Original ResearchMeSH KeywordsLipid DropletsLipid MetabolismLipidsMembrane ProteinsNuclear EnvelopeSaccharomyces cerevisiae