2024
Mechanics of spindle orientation in human mitotic cells is determined by pulling forces on astral microtubules and clustering of cortical dynein
Anjur-Dietrich M, Gomez Hererra V, Farhadifar R, Wu H, Merta H, Bahmanyar S, Shelley M, Needleman D. Mechanics of spindle orientation in human mitotic cells is determined by pulling forces on astral microtubules and clustering of cortical dynein. Developmental Cell 2024, 59: 2429-2442.e4. PMID: 38866013, DOI: 10.1016/j.devcel.2024.05.022.Peer-Reviewed Original Research
2021
Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation
Merta H, Carrasquillo Rodríguez JW, Anjur-Dietrich MI, Vitale T, Granade ME, Harris TE, Needleman DJ, Bahmanyar S. Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation. Developmental Cell 2021, 56: 3364-3379.e10. PMID: 34852214, PMCID: PMC8692360, DOI: 10.1016/j.devcel.2021.11.009.Peer-Reviewed Original ResearchConceptsChromosome missegregationEndoplasmic reticulumLipin-1Accurate chromosome segregationER membrane biogenesisCell cycle regulationPhosphatidic acid phosphatase lipin-1Chromosome segregationMembrane biogenesisER membraneChromosome movementMitotic fidelityCycle regulationER sizeMitosis resultsMitotic cytoplasmFormation of micronucleiMitotic cellsMitotic errorsMissegregationER reorganizationHuman cellsBiophysical propertiesCancer cellsLipid metabolism