2024
Kidney Transplant Outcomes From Deceased Donors Who Received Dialysis
Wen Y, Mansour S, Srialluri N, Hu D, Philbrook H, Hall I, Doshi M, Mohan S, Reese P, Parikh C. Kidney Transplant Outcomes From Deceased Donors Who Received Dialysis. JAMA 2024, 332: 215-225. PMID: 38780515, PMCID: PMC11117155, DOI: 10.1001/jama.2024.8469.Peer-Reviewed Original ResearchDeath-censored graft failureKidney transplant recipientsGraft failureDeceased kidney donorsKidney transplantationTransplant recipientsGraft functionDeceased donorsFollow-upHigher risk of delayed graft functionIncidence of delayed graft functionOutcomes of transplant recipientsRisk of delayed graft functionMedian follow-upKidney donorsDelayed graft functionUS organ procurement organizationsKidney transplant outcomesRetrospective cohort studyRecipients of kidneysKidney donation
2022
Clinically adjudicated deceased donor acute kidney injury and graft outcomes
Mansour SG, Khoury N, Kodali R, Virmani S, Reese PP, Hall IE, Jia Y, Yamamoto Y, Thiessen-Philbrook HR, Obeid W, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Singh P, Weng FL, Moledina DG, Greenberg JH, Wilson FP, Parikh CR. Clinically adjudicated deceased donor acute kidney injury and graft outcomes. PLOS ONE 2022, 17: e0264329. PMID: 35239694, PMCID: PMC8893682, DOI: 10.1371/journal.pone.0264329.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryGraft failureAKI phenotypesKidney injuryUrine biomarkersLack of associationAKI casesGraft functionHigher DGFPotential kidneyGraft outcomeDeceased donorsOrgan utilizationMCP-1YKL-40Donor StudyEGFRDGFAncillary analysisAvailable chartsBiomarkersInjuryPhenotypeAssociation
2020
Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes.
Mansour SG, Liu C, Jia Y, Reese PP, Hall IE, El-Achkar TM, LaFavers KA, Obeid W, Rosenberg AZ, Daneshpajouhnejad P, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, El-Khoury JM, Weng FL, Thiessen-Philbrook HR, Parikh CR. Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes. Transplantation 2020, 105: 876-885. PMID: 32769629, PMCID: PMC8805736, DOI: 10.1097/tp.0000000000003299.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsBiomarkersCells, CulturedDelayed Graft FunctionFemaleGlomerular Filtration RateGraft SurvivalHistocompatibility Antigens Class IIHumansKidneyKidney TransplantationMacrophagesMaleMiceMiddle AgedOsteopontinProspective StudiesRisk AssessmentRisk FactorsTime FactorsTissue DonorsUnited StatesUromodulinConceptsGraft failureGraft functionGraft outcomePrimary outcomeMajor histocompatibilityDeath-censored graft failureDeceased donor kidney transplantationCause graft failureImproved graft survivalRecipient graft outcomesKidney graft outcomeGlomerular filtration rateDeceased donor kidneysTime of procurementGraft survivalKidney transplantationDirection of associationDeceased donorsFiltration rateKidney qualityLower riskExtensive injuryDonor urineSimilar associationMouse macrophagesAssociation of Deceased Donor Acute Kidney Injury With Recipient Graft Survival
Liu C, Hall IE, Mansour S, Philbrook H, Jia Y, Parikh CR. Association of Deceased Donor Acute Kidney Injury With Recipient Graft Survival. JAMA Network Open 2020, 3: e1918634. PMID: 31913491, PMCID: PMC6991314, DOI: 10.1001/jamanetworkopen.2019.18634.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryRecipient graft survivalDeath-censored graft failureCause graft failureAKI kidneysDeceased donorsGraft failureGraft survivalOrgan procurement organizationsAKI statusGraft functionKidney injuryPrimary nonfunctionMean agePropensity score-matched cohort studyTerminal serum creatinine levelPropensity score-matched analysisFollowing secondary outcomesDelayed graft functionSerum creatinine levelsProcurement organizationsDeceased donor kidneysDates of analysisAKI stage
2018
Deceased-donor acute kidney injury is not associated with kidney allograft failure
Hall IE, Akalin E, Bromberg JS, Doshi MD, Greene T, Harhay MN, Jia Y, Mansour SG, Mohan S, Muthukumar T, Reese PP, Schröppel B, Singh P, Thiessen-Philbrook HR, Weng FL, Parikh CR. Deceased-donor acute kidney injury is not associated with kidney allograft failure. Kidney International 2018, 95: 199-209. PMID: 30470437, PMCID: PMC6331055, DOI: 10.1016/j.kint.2018.08.047.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryCause graft failureGraft survivalGraft failureGraft functionKidney injuryComposite outcomeDeceased donorsDonor-recipient gender combinationsLong-term allograft survivalKidney Donor Profile IndexDonor AKI stageExpanded-criteria donationKidney allograft failureUtilization of kidneysGlomerular filtration rateCold ischemia timePre-specified variablesKidney machine perfusionAKI stageAllograft failureAllograft survivalCardiac deathIschemia time
2017
Associations Between Deceased-Donor Urine MCP-1 and Kidney Transplant Outcomes
Mansour SG, Puthumana J, Reese PP, Hall IE, Doshi MD, Weng FL, Schröppel B, Thiessen-Philbrook H, Bimali M, Parikh CR. Associations Between Deceased-Donor Urine MCP-1 and Kidney Transplant Outcomes. Kidney International Reports 2017, 2: 749-758. PMID: 28730184, PMCID: PMC5512592, DOI: 10.1016/j.ekir.2017.03.007.Peer-Reviewed Original ResearchDelayed graft functionAcute kidney injuryMonocyte chemoattractant protein-1MCP-1 concentrationsUMCP-1Graft failureDonor Acute Kidney InjuryRecipient delayed graft functionUrine MCP-1Deceased kidney donorsKidney transplant outcomesChemoattractant protein-1Organ procurement organizationsMinimal clinical utilityAllograft functionAllograft outcomesGraft functionKidney injuryTransplant outcomesKidney procurementStudy cohortKidney donorsIndependent associationMacrophage recruitmentClinical utility