2013
Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases
Petit CS, Roczniak-Ferguson A, Ferguson SM. Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases. Journal Of Cell Biology 2013, 202: 1107-1122. PMID: 24081491, PMCID: PMC3787382, DOI: 10.1083/jcb.201307084.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBlotting, WesternCarrier ProteinsCytoplasmFluorescent Antibody TechniqueHumansImmunoprecipitationLysosomesMechanistic Target of Rapamycin Complex 1Monomeric GTP-Binding ProteinsMultiprotein ComplexesProto-Oncogene ProteinsRecombinant ProteinsRNA, Small InterferingTOR Serine-Threonine KinasesTumor Suppressor ProteinsConceptsAmino acid-dependent activationAcid-dependent activationTranscription factor EBRag GTPasesSurface of lysosomesMTORC1-dependent phosphorylationAmino acid depletionLysosome recruitmentGTPase domainRAG interactionsCytoplasmic sequestrationLysosome functionGTPasesFLCNHuman diseasesFunction mutationsDevelopment of pneumothoraxProtein 1Direct interactionLysosomesCritical rolePulmonary cystsSite of actionAcid depletionFolliculin gene
2012
Dynamin 2 regulates S1P1 signalling and T cell migration (173.15)
Willinger T, Ferguson S, De Camilli P, Flavell R. Dynamin 2 regulates S1P1 signalling and T cell migration (173.15). The Journal Of Immunology 2012, 188: 173.15-173.15. DOI: 10.4049/jimmunol.188.supp.173.15.Peer-Reviewed Original ResearchDynamin 2Cell egressCell migrationT cell-specific deletionT cell egressReceptor-mediated endocytosisVesicle scissionLarge GTPaseCell-specific deletionCell motilityT cell migrationUnexpected roleReceptor internalizationCell surfaceSphingosine 1General defectDynaminAgonist stimulationMigratory responseEndocytosisS1P receptorsThymic egressCritical roleEgressS1P1