2014
Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells
Whirledge S, Senbanjo LT, Cidlowski JA. Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells. Environmental Health Perspectives 2014, 123: 80-87. PMID: 25136773, PMCID: PMC4286279, DOI: 10.1289/ehp.1408437.Peer-Reviewed Original ResearchConceptsTarget genesWhole-genome microarray analysisIshikawa cellsGlucocorticoid receptorGenome microarray analysisCommon gene targetsGR target genesTranscriptional responseNumerous genesDisruption of GRTranscriptional antagonismGlucocorticoid receptor signalingEnvironmental estrogen exposureRegulation of stressGene targetsSelect genesGene expressionCoadministration of genisteinEndometrial Ishikawa cellsMicroarray analysisReal-time reverse transcription-polymerase chain reactionFemale reproductive tractReverse transcription-polymerase chain reactionGenesQuantitative real-time reverse transcription-polymerase chain reaction
2013
Global Gene Expression Analysis in Human Uterine Epithelial Cells Defines New Targets of Glucocorticoid and Estradiol Antagonism1
Whirledge S, Xu X, Cidlowski JA. Global Gene Expression Analysis in Human Uterine Epithelial Cells Defines New Targets of Glucocorticoid and Estradiol Antagonism1. Biology Of Reproduction 2013, 89: 66, 1-17. PMID: 23843231, PMCID: PMC4435104, DOI: 10.1095/biolreprod.113.111054.Peer-Reviewed Original ResearchConceptsImmune systemUterine endometrial cancer cell lineUterine epitheliumEndometrial cancer cell linesHuman uterine epithelial cellsMaintenance of pregnancyEffects of glucocorticoidsImmune cell traffickingSynthetic glucocorticoid dexamethasoneCell linesEpithelial-like cell lineFemale reproductive systemPresence of DexGlucocorticoid-regulated genesIngenuity Pathway AnalysisUterine epithelial cellsCancer cell linesInflammatory responseReproductive hormonesEstrogen receptorGlucocorticoid signalingEmbryo implantationGlucocorticoid dexamethasoneGlucocorticoid receptorGlucocorticoids