2016
Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy
Zhou J, Ahmad F, Parikh S, Hoffman NE, Rajan S, Verma VK, Song J, Yuan A, Shanmughapriya S, Guo Y, Gao E, Koch W, Woodgett JR, Madesh M, Kishore R, Lal H, Force T. Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy. Circulation Research 2016, 118: 1208-1222. PMID: 26976650, PMCID: PMC4843504, DOI: 10.1161/circresaha.116.308544.Peer-Reviewed Original ResearchConceptsAdult cardiac myocytesCardiac myocytesCardiac homeostasisGSK-3βSerial echocardiographic analysisCardiac myocyte-specific deletionGSK-3Normal cardiac homeostasisMitotic catastropheCell cycle dysregulationDouble knockout heartsVentricular dysfunctionOverall survivalTamoxifen treatmentCardiac protectionMyocardial infarctionEchocardiographic analysisHeart functionGlycogen synthase kinaseIsolated adult cardiac myocytesSynergistic protectionGSK-3 isoformsCell cycle activityMarked activationCell cycle progression
2014
Troponin I-Interacting Protein Kinase
Lal H, Ahmad F, Parikh S, Force T. Troponin I-Interacting Protein Kinase. Circulation Journal 2014, 78: 1514. PMID: 24899531, PMCID: PMC4151348, DOI: 10.1253/circj.cj-14-0543.Peer-Reviewed Original ResearchConceptsIR injuryMyocardial infarctionCardiomyocyte deathNew drug targetsNovel genetic animal modelsEffective myocardial reperfusionAcute coronary syndromeIschemia-reperfusion injuryPercutaneous coronary interventionCoronary artery diseaseCause of deathProfound oxidative stressPromising new drug targetGenetic animal modelsCardiac troponin ITNNI3KDrug targetsCoronary syndromeCoronary interventionArtery diseaseMyocardial reperfusionReperfusion injuryCardiac dysfunctionIschemic injuryInfarct size