2018
Distribution of Human Immunodeficiency Virus (HIV) Ribonucleic Acid in Cerebrospinal Fluid and Blood Is Linked to CD4/CD8 Ratio During Acute HIV
Chan P, Patel P, Hellmuth J, Colby DJ, Kroon E, Sacdalan C, Pinyakorn S, Jagodzinski L, Krebs S, Ananworanich J, Valcour V, Spudich S, Team R. Distribution of Human Immunodeficiency Virus (HIV) Ribonucleic Acid in Cerebrospinal Fluid and Blood Is Linked to CD4/CD8 Ratio During Acute HIV. The Journal Of Infectious Diseases 2018, 218: 937-945. PMID: 29741638, PMCID: PMC6093332, DOI: 10.1093/infdis/jiy260.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultCD4-CD8 RatioCentral Nervous SystemFemaleHIVHIV InfectionsHumansMaleRNA, ViralThailandVirus InternalizationYoung AdultConceptsCD4/CD8 ratioCSF HIV RNAHIV RNACD8 ratioCerebrospinal fluidHIV infectionHuman immunodeficiency virus ribonucleic acidCerebrospinal fluid (CSF) immune markersLog10 copies/mLStage I/IIHuman immunodeficiency virus (HIV) RNAChronic HIV infectionHigher CSF neopterinAcute HIV infectionPlasma HIV RNACopies/mLHuman immunodeficiency virus ribonucleic acid levelsRibonucleic acid levelsVirus ribonucleic acidAcute HIVCSF neopterinSCD14 levelsAcute infectionMedian ageImmune markers
2015
Phenotypic Correlates of HIV-1 Macrophage Tropism
Arrildt KT, LaBranche CC, Joseph SB, Dukhovlinova EN, Graham WD, Ping LH, Schnell G, Sturdevant CB, Kincer LP, Mallewa M, Heyderman RS, Van Rie A, Cohen MS, Spudich S, Price RW, Montefiori DC, Swanstrom R. Phenotypic Correlates of HIV-1 Macrophage Tropism. Journal Of Virology 2015, 89: 11294-11311. PMID: 26339058, PMCID: PMC4645658, DOI: 10.1128/jvi.00946-15.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCD4 AntigensCD4-Positive T-LymphocytesCell Line, TumorHEK293 CellsHIV Envelope Protein gp120HIV Envelope Protein gp160HIV Envelope Protein gp41HIV InfectionsHIV-1HumansMacrophagesReceptors, CCR5Recombinant ProteinsViral TropismVirus InternalizationConceptsT cell-tropic virusesT-tropic virusesMonocyte-derived macrophagesM-tropic virusesMacrophage-tropic virusesV1/V2 regionSoluble CD4Central nervous systemHIV-1Chronic infectionT cellsMacrophage-tropic HIV-1 variantsNervous systemM-tropic HIV-1HIV-1 env geneEnv proteinV2 regionT-cell tropicHIV-1 variantsCD4-bound conformationMacrophage-tropicMacrophage tropismM-tropicSurface CD4CD4
2012
HIV-1-Related Central Nervous System Disease: Current Issues in Pathogenesis, Diagnosis, and Treatment
Spudich S, González-Scarano F. HIV-1-Related Central Nervous System Disease: Current Issues in Pathogenesis, Diagnosis, and Treatment. Cold Spring Harbor Perspectives In Medicine 2012, 2: a007120. PMID: 22675662, PMCID: PMC3367536, DOI: 10.1101/cshperspect.a007120.Peer-Reviewed Original ResearchConceptsHIV infectionLate-stage HIV infectionCentral nervous system injuryOptimal antiretroviral therapyNeuropathogenesis of HIVTreatment of HIVNervous system injuryLong-term survivalAntiretroviral therapyCNS complicationsAntiretroviral medicationsViral neuroinvasionSystem injuryCNS injuryClinical studiesNeurological abnormalitiesUnderresourced settingsNeuropsychological testingHIVInfectionSubstantial proportionTherapyInjuryTreatmentCurrent era