Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot study
Ho EL, Spudich SS, Lee E, Fuchs D, Sinclair E, Price RW. Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot study. AIDS Research And Therapy 2011, 8: 17. PMID: 21569420, PMCID: PMC3117676, DOI: 10.1186/1742-6405-8-17.Peer-Reviewed Original ResearchCerebrospinal fluidHIV infectionImmune activationPilot studyCSF white blood cell countBlood HIV-1 RNAChronic untreated HIV infectionUntreated HIV-1 infectionWhite blood cell countCell surface activation markersCNS HIV infectionUntreated HIV infectionHIV-1 infectionHIV-1 RNABlood cell countBlood T lymphocytesConclusionsThis pilot studyBlood neopterinCSF CCL2Adjuvant therapyAntiretroviral therapyViremic subjectsActivation markersBlood biomarkersBrain injury