2014
Treatment of HIV in the CNS: Effects of Antiretroviral Therapy and the Promise of Non-Antiretroviral Therapeutics
Peluso MJ, Spudich S. Treatment of HIV in the CNS: Effects of Antiretroviral Therapy and the Promise of Non-Antiretroviral Therapeutics. Current HIV/AIDS Reports 2014, 11: 353-362. PMID: 25063356, DOI: 10.1007/s11904-014-0223-y.Peer-Reviewed Original ResearchConceptsCentral nervous systemAntiretroviral therapyNew neurologic abnormalitiesTrajectory of HIVAIDS dementia complexSpectrum of HIVTreatment of HIVPersistent handViral suppressionNeurologic manifestationsAsymptomatic diseaseHIV infectionNeurologic abnormalitiesNeurocognitive disordersNeurologic diseaseNeurocognitive dysfunctionTherapeutic modalitiesNervous systemHIVSevere impairmentTherapyDiseasePatientsDysfunctionPathophysiology
2013
HIV and Neurocognitive Dysfunction
Spudich S. HIV and Neurocognitive Dysfunction. Current HIV/AIDS Reports 2013, 10: 235-243. PMID: 23860944, PMCID: PMC3732773, DOI: 10.1007/s11904-013-0171-y.Peer-Reviewed Original ResearchConceptsIrreversible CNS injuryEffective antiretroviral therapySpectrum of HIVQuality of lifeEffect of treatmentCommunity of patientsAntiretroviral therapyCNS infectionNeurologic injuryHIV infectionProgressive injuryImmune activationCNS injuryCognitive dysfunctionNeurocognitive disordersNeurocognitive dysfunctionHIVCognitive impairmentViral replicationInjuryBeneficial reductionDysfunctionInfectionDisordersPatients