Feasibility and safety of research sigmoid colon biopsy in a cohort of Thai men who have sex with men with acute HIV-1
Chintanaphol M, Sacdalan C, Pinyakorn S, Rerknimitr R, Ridtitid W, Prueksapanich P, Sereti I, Schuetz A, Crowell TA, Colby DJ, Robb ML, Phanuphak N, Ananworanich J, Spudich SS, Kroon E. Feasibility and safety of research sigmoid colon biopsy in a cohort of Thai men who have sex with men with acute HIV-1. Journal Of Virus Eradication 2020, 6: 7-10. PMID: 32175085, PMCID: PMC7043900, DOI: 10.1016/s2055-6640(20)30011-x.Peer-Reviewed Original ResearchAcute HIV-1 infectionGut-associated lymphoid tissueHIV-1 reservoirSigmoid colon biopsiesAdverse eventsAE riskSigmoid colonColon biopsiesHIV-1CD4 T-cell depletionCD4 T-cell countAcute HIV-1Mild rectal bleedingAdverse event incidenceT-cell countsHigh viral replicationT-cell depletionHIV-1 infectionHIV-1 RNATime of biopsyIncidence rate ratiosRectal bleedingAbdominal discomfortEvent incidenceViral load