2015
Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection
Sturdevant CB, Joseph SB, Schnell G, Price RW, Swanstrom R, Spudich S. Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection. PLOS Pathogens 2015, 11: e1004720. PMID: 25811757, PMCID: PMC4374811, DOI: 10.1371/journal.ppat.1004720.Peer-Reviewed Original ResearchConceptsCentral nervous systemSingle genome amplificationHIV-1 RNA concentrationsHIV-1 replicationInflammatory responseViral replicationHIV-1Nervous systemCSF HIV-1 RNA concentrationsIndependent HIV-1 replicationT-cell-tropic HIV-1Full-length env sequencesART-naïve subjectsCNS viral replicationCSF inflammatory responseTime pointsLocal viral replicationYears of infectionMonths of infectionRNA concentrationViral populationsCellular inflammatory responseCourse of infectionTransmitted variantsPopulation of subjects
2009
Compartmentalization and Clonal Amplification of HIV-1 Variants in the Cerebrospinal Fluid during Primary Infection
Schnell G, Price RW, Swanstrom R, Spudich S. Compartmentalization and Clonal Amplification of HIV-1 Variants in the Cerebrospinal Fluid during Primary Infection. Journal Of Virology 2009, 84: 2395-2407. PMID: 20015984, PMCID: PMC2820937, DOI: 10.1128/jvi.01863-09.Peer-Reviewed Original ResearchConceptsHIV-1 populationsPrimary HIV-1 infectionCentral nervous systemHIV-1 infectionHIV-1 variantsDistinct HIV-1 populationsIndependent HIV-1 replicationHIV-1-infected individualsHuman immunodeficiency virus type 1Full-length env genesImmunodeficiency virus type 1HIV-1 transmissionSingle genome amplificationHIV-1 replicationHeteroduplex tracking assaysCourse of infectionSubset of subjectsVirus type 1Severe neurological diseaseClonal amplificationPeripheral bloodPrimary infectionCNS environmentCerebrospinal fluidNervous system