2024
New approaches for understanding the potential role of microbes in Alzheimer's disease
Whitson H, Banks W, Diaz M, Frost B, Kellis M, Lathe R, Schmader K, Spudich S, Tanzi R, Garden G. New approaches for understanding the potential role of microbes in Alzheimer's disease. Brain Behavior & Immunity - Health 2024, 36: 100743. PMID: 38435720, PMCID: PMC10906156, DOI: 10.1016/j.bbih.2024.100743.Peer-Reviewed Original ResearchAlzheimer's diseaseAD pathologyAntimicrobial protection hypothesisInfluence AD pathologyGene-environment interactionsModel organismsMicrobial organismsMicrobesPotential roleAmyloid accumulationProtection hypothesisAlzheimerImmune cell activationReview new evidencePathological processesCell activationComplex pathological processAmyloidGermOrganizationAlzheimer's Disease Research Center
2022
Infection and inflammation: New perspectives on Alzheimer's disease
Whitson HE, Colton C, Khoury J, Gate D, Goate A, Heneka MT, Kaddurah-Daouk R, Klein RS, Shinohara ML, Sisodia S, Spudich SS, Stevens B, Tanzi R, Ting JP, Garden G, members S, Aiello A, Chiba-Falek O, Heitman J, Johnson K, Luftig M, Moseman A, Rawls J, Shinohara M, Swanstrom R, Terrando N. Infection and inflammation: New perspectives on Alzheimer's disease. Brain Behavior & Immunity - Health 2022, 22: 100462. PMID: 36118272, PMCID: PMC9475126, DOI: 10.1016/j.bbih.2022.100462.Peer-Reviewed Original ResearchDisease Research CenterAlzheimer's diseaseAD pathogenesisSelf-reactive T cellsDisease pathologyCOVID-19 patientsAlzheimer's Disease Research CenterAlzheimer's disease pathologyNeurologic symptomsInflammatory cellsT cellsMouse modelCurrent evidenceHuman immunityAlois AlzheimerMetabolic alterationsCommensal microbesFungal infectionsInfectionDiseasePotential involvementInflammationPathogenesisFunctional stateNeuroinflammation