2014
TLR9 restricts survival of anergic anti-DNA B cells in systemic lupus erythematosus yet is also required for their activation (BA4P.219)
Nickerson K, Christensen S, Cullen J, Meng W, Luning Prak E, Shlomchik M. TLR9 restricts survival of anergic anti-DNA B cells in systemic lupus erythematosus yet is also required for their activation (BA4P.219). The Journal Of Immunology 2014, 192: 46.10-46.10. DOI: 10.4049/jimmunol.192.supp.46.10.Peer-Reviewed Original ResearchAnti-DNA B cellsSystemic lupus erythematosusB cellsB cell receptorAnti-DNA autoantibodiesLupus erythematosusBreaking B-cell toleranceAbsence of TLR9Reactive B cellsAutoimmunity in vivoB cell toleranceAutoimmune-prone MRLFunctional anergyAutoreactive cellsPeripheral repertoireAnergic cellsBone marrowExtrafollicular pathwayReceptor editingClinical hallmarkBCR signalingMouse modelBCR expressionTLR9Healthy individuals
2013
TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation
Nickerson KM, Christensen SR, Cullen JL, Meng W, Prak E, Shlomchik MJ. TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation. The Journal Of Immunology 2013, 190: 1447-1456. PMID: 23296704, PMCID: PMC3563726, DOI: 10.4049/jimmunol.1202115.Peer-Reviewed Original ResearchConceptsAnti-DNA B cellsB cellsBone marrowAbsence of TLR9Autoimmune prone animalsAutoimmune-prone MRLSystemic lupus erythematosusAnergic B cellsB cell compartmentB cell toleranceAb-forming cellsL chain editingB cell life spanFunctional anergyLupus erythematosusTLR9 expressionAutoreactive cellsPeripheral activationExtrafollicular pathwayPeripheral repertoireSystemic autoimmunityMouse modelAnergic cellsTLR9Cell life span