1998
Identifying RNA Minor Groove Tertiary Contacts by Nucleotide Analogue Interference Mapping with N 2-Methylguanosine †
Ortoleva-Donnelly L, Kronman M, Strobel S. Identifying RNA Minor Groove Tertiary Contacts by Nucleotide Analogue Interference Mapping with N 2-Methylguanosine †. Biochemistry 1998, 37: 12933-12942. PMID: 9737873, DOI: 10.1021/bi980723j.Peer-Reviewed Original ResearchN2-Methylguanosine is iso-energetic with guanosine in RNA duplexes and GNRA tetraloops
Rife J, Cheng C, Moore P, Strobel S. N2-Methylguanosine is iso-energetic with guanosine in RNA duplexes and GNRA tetraloops. Nucleic Acids Research 1998, 26: 3640-3644. PMID: 9685477, PMCID: PMC147776, DOI: 10.1093/nar/26.16.3640.Peer-Reviewed Original ResearchConceptsM2GGNRA tetraloopRNA duplexesG substitutionSecondary structural stabilityHypermethylated regionsRNA structureNatural RNAPossible functionsRNAWatson-Crick pairsTetraloopNucleotidesN2-methylguanosineRibosomesRRNADuplexMethylationThermodynamic consequencesSubstitutionWide varietyDuplex stabilityPairsFunctionGuanosine
1997
RNA seeing double: Close-packing of helices in RNA tertiary structure
Strobel S, Doudna J. RNA seeing double: Close-packing of helices in RNA tertiary structure. Trends In Biochemical Sciences 1997, 22: 262-266. PMID: 9255068, DOI: 10.1016/s0968-0004(97)01056-6.Peer-Reviewed Original ResearchMeSH KeywordsBase CompositionModels, MolecularMolecular StructureNucleic Acid ConformationProteinsRNAConceptsHigher-order structure formationPacking of helicesChromosome maintenanceNoncanonical base pairsRNA processingDouble-helical segmentsRNA tertiary structureProtein biosynthesisRecognition motifRNA moleculesTertiary structureBase pairsHelical packingRNAEssential roleProteinActive siteBiosynthesisComplex architectureFoldingMotifHelixAssemblyDifferent strategies
1995
Minor Groove Recognition of the Conserved G⋅U Pair at the Tetrahymena ribozyme Reaction Site
Strobel S, Cech T. Minor Groove Recognition of the Conserved G⋅U Pair at the Tetrahymena ribozyme Reaction Site. Science 1995, 267: 675-679. PMID: 7839142, DOI: 10.1126/science.7839142.Peer-Reviewed Original Research
1994
The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA.
Strobel S, Cech T, Usman N, Beigelman L. The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA. Biochemistry 1994, 33: 13824-35. PMID: 7524665, DOI: 10.1021/bi00250a037.Peer-Reviewed Original Research