2001
pH-dependent conformational flexibility within the ribosomal peptidyl transferase center.
Muth G, Chen L, Kosek A, Strobel S. pH-dependent conformational flexibility within the ribosomal peptidyl transferase center. RNA 2001, 7: 1403-15. PMID: 11680845, PMCID: PMC1370184.Peer-Reviewed Original ResearchExploring the mechanism of the peptidyl transfer reaction by chemical footprinting.
Strobel S, Muth G, Chen L. Exploring the mechanism of the peptidyl transfer reaction by chemical footprinting. Cold Spring Harbor Symposia On Quantitative Biology 2001, 66: 109-17. PMID: 12762013, DOI: 10.1101/sqb.2001.66.109.Peer-Reviewed Original Research
1991
Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation
Strobel S, Dervan P. Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation. Nature 1991, 350: 172-174. PMID: 1848684, DOI: 10.1038/350172a0.Peer-Reviewed Original ResearchConceptsTriple helix formationGenomic DNABase pairsYeast genomic DNAHelix formationSequence-specific DNALarge genomic DNAGenomic libraryMegabase pairsPhysical mappingEnzymatic cleavageRecognition motifSpecificity of bindingChromosomal DNARestriction endonuclease digestionManageable fragmentsRecognition sequenceGenetic markersDNA showRestriction enzymesQuantitative cleavageLarge DNADNAEndonuclease digestionChromosomes
1990
Site-Specific Cleavage of a Yeast Chromosome by Oligonucleotide-Directed Triple-Helix Formation
Strobel S, Dervan P. Site-Specific Cleavage of a Yeast Chromosome by Oligonucleotide-Directed Triple-Helix Formation. Science 1990, 249: 73-75. PMID: 2195655, DOI: 10.1126/science.2195655.Peer-Reviewed Original Research