2018
Positive surgical margins in parotid malignancies: Institutional variation and survival association
Morse E, Fujiwara RJT, Judson B, Prasad ML, Mehra S. Positive surgical margins in parotid malignancies: Institutional variation and survival association. The Laryngoscope 2018, 129: 129-137. PMID: 30194762, DOI: 10.1002/lary.27221.Peer-Reviewed Original ResearchConceptsPositive surgical marginsPositive margin rateOverall survivalSurgical marginsHigh-volume facilitiesMargin ratePositive marginsParotid malignanciesMucoepidermoid carcinomaCox proportional hazards regressionOverall positive margin rateLow-grade mucoepidermoid carcinomaNational Cancer DatabaseProportional hazards regressionMultivariable logistic regressionPositive margin statusRetrospective database analysisParotid cancerMargin statusHazards regressionCancer DatabaseSurvival associationsDecreased oddsCystic carcinomaPatients
2016
NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
Panaccione A, Chang MT, Carbone BE, Guo Y, Moskaluk CA, Virk RK, Chiriboga L, Prasad ML, Judson B, Mehra S, Yarbrough WG, Ivanov SV. NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma. Clinical Cancer Research 2016, 22: 2083-2095. PMID: 27084744, PMCID: PMC4834904, DOI: 10.1158/1078-0432.ccr-15-2208.Peer-Reviewed Original ResearchMeSH KeywordsAC133 AntigenAmyloid Precursor Protein SecretasesAnimalsBiomarkers, TumorCarcinoma, Adenoid CysticCell Line, TumorCell Transformation, NeoplasticCyclin-Dependent Kinase Inhibitor p27Disease Models, AnimalFatty Acid-Binding Protein 7Gene Expression ProfilingHeterograftsHumansLigandsMiceMice, NudeNeoplasm GradingNeoplastic Stem CellsProtein BindingRadiationRadiation ToleranceReceptor, Notch1S-Phase Kinase-Associated ProteinsSOXE Transcription FactorsTumor Cells, CulturedTumor Suppressor ProteinsConceptsCancer stem cellsRibosome biogenesisCancer stem-like cellsStem-like cellsLack of assaysCSC maintenanceMolecular markersNeural differentiationCell deathUncharacterized populationACC therapyΓ-secretase inhibitorCSC viabilityCD133-positive cancer stem cellsStem cellsCell sortingSOX10Essential roleSkp2Notch1P27Kip1Stem propertiesCell culturesImmunomagnetic cell sortingCells