2021
Multi-Residency Implementation of an Online Movement Disorders Curriculum Based on Real Patient Videos
Schaefer SM, London Z, Ferrara JM, McCoyd MA, Cronin C, Pharr EP, Price R, Rigby HB, Vota S, Cincotta M, Slade MD, Moeller JJ. Multi-Residency Implementation of an Online Movement Disorders Curriculum Based on Real Patient Videos. Tremor And Other Hyperkinetic Movements 2021, 11: 38. PMID: 34621598, PMCID: PMC8462470, DOI: 10.5334/tohm.654.Peer-Reviewed Original ResearchConceptsIntervention groupMovement disordersImmediate postResidency programsIntervention group residentsMultiple residency programsInteractive online curriculumNeurology residency programsControl residentsClinical exposureGroup residentsPatient videosVariable periodDidactic educationModule completionInconsistent availabilityDisordersHigher scoresScoresGroupClinical learningExposureOnline curriculumResidentsLeast half
2020
Deep Brain Stimulation Target Selection in Co-Morbid Essential Tremor and Parkinson’s Disease
Wadhwa A, Schaefer S, Gerrard J, Deeb W, Okun MS, Patel A. Deep Brain Stimulation Target Selection in Co-Morbid Essential Tremor and Parkinson’s Disease. Tremor And Other Hyperkinetic Movements 2020, 10: 17. PMID: 32775031, PMCID: PMC7394224, DOI: 10.5334/tohm.62.Peer-Reviewed Original ResearchConceptsDeep brain stimulationParkinson's diseaseEssential tremorHead trialsDBS targetsAction tremorSubthalamic nucleus (STN) DBSThalamus deep brain stimulationLimited evidenceDBS target selectionVentral intermediate nucleusBilateral STNPD patientsDBS treatmentEquivalent efficacyRest tremorMild improvementCurrent evidenceET patientsET tremorBrain stimulationComparative efficacyPatientsExpert consensusTremor reductionImplications of the Gut Microbiome in Parkinson's Disease
Elfil M, Kamel S, Kandil M, Koo BB, Schaefer SM. Implications of the Gut Microbiome in Parkinson's Disease. Movement Disorders 2020, 35: 921-933. PMID: 32092186, DOI: 10.1002/mds.28004.Peer-Reviewed Original ResearchConceptsParkinson's disease patientsDisease patientsParkinson's diseaseMotor symptomsNervous systemEnteric nervous systemGut microbiome dysbiosisGut microbiome changesDifferent body systemsRelease of neurotoxinsCentral nervous systemCommon neurodegenerative disorderNormal gut microbiomeΑ-synuclein aggregatesNonmotor manifestationsAutoimmune responseNeuroprotective factorsAutopsy studyDopaminergic neuronsSubstantia nigraPathophysiologic changesMicrobiome dysbiosisMotor featuresGastrointestinal systemSystemic circulation
2019
Successful Treatment of Primary Orthostatic Tremor Using Perampanel
Wadhwa A, Schaefer SM. Successful Treatment of Primary Orthostatic Tremor Using Perampanel. Tremor And Other Hyperkinetic Movements 2019, 9 PMID: 31413897, PMCID: PMC6691907, DOI: 10.7916/tohm.v0.681.Peer-Reviewed Original Research
2018
The Future of the Lecture in Neurology Education
Schaefer SM, Dominguez M, Moeller JJ. The Future of the Lecture in Neurology Education. Seminars In Neurology 2018, 38: 418-427. PMID: 30125896, DOI: 10.1055/s-0038-1667042.Peer-Reviewed Original ResearchConceptsNeurology educationMedical educationComputer-based learning moduleProblem-based learningTeam-based learningAlternative teaching methodsSelf-directed learningModern medical curriculumSelf-study activitiesModern medical educationVideo-based lecturesModern learning theoryFormal medical educationFlipped classroomPedagogical methodsTeaching methodsTraditional lectureTime teachingMedical curriculumLearning modulesFormal lecturesLearning theoryClinical reasoningEducationLecturesA Neurology Clerkship Curriculum Using Video-Based Lectures and Just-in-Time Teaching (JiTT)
Dominguez M, DiCapua D, Leydon G, Loomis C, Longbrake EE, Schaefer SM, Becker KP, Detyniecki K, Gottschalk C, Salardini A, Encandela JA, Moeller JJ. A Neurology Clerkship Curriculum Using Video-Based Lectures and Just-in-Time Teaching (JiTT). MedEdPORTAL 2018, 14: 10691. PMID: 30800891, PMCID: PMC6342385, DOI: 10.15766/mep_2374-8265.10691.Peer-Reviewed Original ResearchConceptsVideo-based lecturesTime teachingStudent performanceMost studentsNeurology clerkshipClerkship examinationStudent focus groupsSurvey of studentsFocus groupsMultiple-choice questionsSense of responsibilityClerkship curriculumLearning activitiesNew curriculumTeaching activitiesClinical clerkshipsPerson lecturesFaculty lecturersEducational strategiesLong lecturesStudentsKnowledge assessmentTeachingCurriculumClerkship
2017
Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches
Schaefer SM, Rodriguez A, Louis ED. Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches. Expert Review Of Neurotherapeutics 2017, 18: 101-110. PMID: 29206482, DOI: 10.1080/14737175.2018.1413353.Peer-Reviewed Original ResearchConceptsEssential tremorGABA systemReceptor subtypesΓ-aminobutyric acid (GABA) neurotransmissionT-type calcium channelsHuman data pointUnderlying biochemical dysfunctionGABA-ergic neuronsRole of GABAInferior olivary nucleusPurkinje cell outputCertain GABANumerous medicationsClinical guidelinesPharmacotherapeutic approachesOlivary nucleusGABA receptorsPubMed searchCalcium channelsBiochemical dysfunctionNeurochemical systemsBrain circuitsMedicationsDegeneration modelGABA