2019
The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors
Chiu JE, Thekkiniath J, Mehta S, Müller C, Bracher F, Ben Mamoun C. The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors. Journal Of Biological Chemistry 2019, 294: 14757-14767. PMID: 31409644, PMCID: PMC6779428, DOI: 10.1074/jbc.ra119.009791.Peer-Reviewed Original ResearchConceptsErgosterol biosynthesis inhibitorsSterol intermediatesBiosynthesis inhibitorsErgosterol biosynthesis genesGenome-wide transcriptionMS-based analysisBiosynthesis genesResistant fungal pathogensMaster regulatorPlasma membraneFungal pathogensCoA biosynthesisErgosterol biosynthesisYeast cellsAntifungal drug terbinafinePantothenate utilizationSterol metabolismBiosynthesisAntifungal amphotericin BAcid utilizationCoA metabolismDrug interaction experimentsPrimary targetMetabolismEssential component
2016
Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy
Ryu HY, Wilson NR, Mehta S, Hwang SS, Hochstrasser M. Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Genes & Development 2016, 30: 1881-1894. PMID: 27585592, PMCID: PMC5024685, DOI: 10.1101/gad.282194.116.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAneuploidyCell CycleChromosomes, FungalEndopeptidasesGene DeletionGene DosageGene Expression Regulation, FungalGenome, FungalRNA, MessengerSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsConceptsSUMO protease Ulp2Small ubiquitin-related modifierPost-translational protein modificationWhole-genome RNA sequencingNumerous cellular pathwaysG1 phase cyclinsGenome maintenanceChromosome IUlp2Particular chromosomeAdapts cellsCell divisionSUMO proteaseCellular stressRNA sequencingProtein modificationCellular pathwaysNormal copy numberTranscript levelsMost human tumorsCopy numberRapid adaptationExtra copiesChromosomesSpecific aneuploidies