c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases
Zeng ZS, Weiser MR, Kuntz E, Chen CT, Khan SA, Forslund A, Nash GM, Gimbel M, Yamaguchi Y, Culliford AT, D’Alessio M, Barany F, Paty PB. c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer Letters 2008, 265: 258-269. PMID: 18395971, PMCID: PMC4367187, DOI: 10.1016/j.canlet.2008.02.049.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorColorectal NeoplasmsFemaleGene AmplificationGene DosageHumansLiver NeoplasmsMaleMiddle AgedPolymerase Chain ReactionProto-Oncogene MasProto-Oncogene Proteins c-metConceptsC-MET gene amplificationC-Met gene copy numberLiver metastasesPrimary colorectal cancerColorectal cancerGene amplificationC-MetAdvanced stage colorectal cancerAdvanced colorectal cancerStage colorectal cancerNormal colonic mucosaLiver resectionTyrosine kinaseGene copy numberDistant metastasisPrimary cancerLung cancerColonic mucosaGastric cancerNormal mucosaMetastasisNormal liverTumor growthMetastatic progressionLiver tissue