The crystal structure of GXGD membrane protease FlaK
Hu J, Xue Y, Lee S, Ha Y. The crystal structure of GXGD membrane protease FlaK. Nature 2011, 475: 528-531. PMID: 21765428, PMCID: PMC3894692, DOI: 10.1038/nature10218.Peer-Reviewed Original ResearchConceptsFamily of proteasesFirst crystal structureIntramembrane proteasesPrepilin peptidaseMethanococcus maripaludisMembrane proteasePreflagellin peptidaseFamilial Alzheimer's diseaseVirulence factorsAspartyl proteaseBiochemical analysisProteasePathogenic bacteriaStructural knowledgePresenilinPeptidaseCrystal structureSoluble counterpartActive siteFamilyRational designAspartylBacteriaAlzheimer's diseaseFundamental differencesCrystal Structure of the E2 Domain of Amyloid Precursor Protein-like Protein 1 in Complex with Sucrose Octasulfate*
Xue Y, Lee S, Wang Y, Ha Y. Crystal Structure of the E2 Domain of Amyloid Precursor Protein-like Protein 1 in Complex with Sucrose Octasulfate*. Journal Of Biological Chemistry 2011, 286: 29748-29757. PMID: 21715329, PMCID: PMC3191016, DOI: 10.1074/jbc.m111.219659.Peer-Reviewed Original ResearchConceptsAPP-like proteinsE2 domainHEK-293 cellsSucrose OctasulfateSignal transductionProtein geneBasic residuesSOS moleculesMutational analysisE2 dimerMost residuesProcessing of APPFamilial Alzheimer's diseaseExtracellular matrixAmyloid precursor protein geneProteolysis of APPMissense mutationsProtein 1Key heparinProteinResiduesSymmetry mateAPLP1Precursor protein geneCrystal structure