2000
The Regulation of Normal Melanocyte Proliferation
Halaban R. The Regulation of Normal Melanocyte Proliferation. Pigment Cell & Melanoma Research 2000, 13: 4-14. PMID: 10761990, DOI: 10.1034/j.1600-0749.2000.130103.x.Peer-Reviewed Original ResearchConceptsTranscription factorsIntracellular signal transduction cascadesE2F transcription factorsImmediate early response genesSignal transduction cascadeHepatocyte growth factor/scatter factorGrowth factorGrowth factor/scatter factorE2F transcriptional activityCyclin-dependent kinasesSynergistic growth factorsNormal human melanocytesPocket proteinsRetinoblastoma familyPeptide growth factorsStem cell factorTransduction cascadeNormal melanocyte proliferationEctopic expressionResponse genesTranscriptional activityFibroblast growth factorMolecular eventsHuman melanocytesIntermediate effectors
1997
Chymase cleavage of stem cell factor yields a bioactive, soluble product
Longley B, Tyrrell L, Ma Y, Williams D, Halaban R, Langley K, Lu H, Schechter N. Chymase cleavage of stem cell factor yields a bioactive, soluble product. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 9017-9021. PMID: 9256427, PMCID: PMC23007, DOI: 10.1073/pnas.94.17.9017.Peer-Reviewed Original ResearchConceptsSoluble SCFCell factorMembrane-bound moleculesMast cell secretory granulesStromal cellsStem cell factorChymotrypsin-like proteaseSCF geneCell secretory granulesC-terminusPossible feedback loopRelevant enzymesNovel siteAmino acidsDifferentiated functionsMast cellsCell proliferationExon 6Secretory granulesHuman mast cell chymaseChronic cutaneous inflammationMast cell chymaseKIT proteinBioactive productsMast cell proliferation