Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study
McNamara R, Schurdak J, Asch R, Lindquist D. Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study. Nutritional Neuroscience 2017, 22: 587-595. PMID: 29286866, PMCID: PMC6251752, DOI: 10.1080/1028415x.2017.1419550.Peer-Reviewed Original ResearchConceptsDEF ratsFO ratsAMPH challengeAmphetamine treatmentDocosahexaenoic acidBOLD activationDHA levelsBilateral caudate putamenBrain DHA levelsErythrocyte DHA levelsNeuroplastic brain changesPharmacological magnetic resonanceBlood oxygen level-dependent (BOLD) responseAlpha-linolenic acidAttention deficit hyperactivity disorderLevel-dependent responsesGreater locomotor activityDeficit hyperactivity disorderDEF animalsBrain activation patternsPhMRI studiesAMPH injectionFatty acidsAMPH exposureBasal forebrainEffects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo 31P MRS study
Lindquist D, Asch R, Schurdak J, McNamara R. Effects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo 31P MRS study. Journal Of Psychiatric Research 2017, 95: 143-146. PMID: 28846858, PMCID: PMC5653412, DOI: 10.1016/j.jpsychires.2017.08.014.Peer-Reviewed Original ResearchConceptsMembrane phospholipid metabolismBrain DHA levelsDietary-induced alterationsDocosahexaenoic acidPhospholipid metabolismRat brainDHA levelsBrain docosahexaenoic acidMagnetic resonance spectroscopy studyAdult rat brainPeri-adolescent periodMitochondrial bioenergeticsDifferent psychiatric disordersAlpha-linolenic acidP MRS dataP-MRSDef dietFatty acidsSignificant group differencesMale ratsPhosphocreatine levelsAdult ratsPsychiatric disordersMRS studiesFO diet