2024
Proteostasis maintenance by macrophage trogocytosis
Kimura Y, Philip N, Chavan A, Medzhitov R. Proteostasis maintenance by macrophage trogocytosis. The Journal Of Immunology 2024, 212: 1318_4183-1318_4183. DOI: 10.4049/jimmunol.212.supp.1318.4183.Peer-Reviewed Original ResearchStressed cellsProtein aggregationCellular fitnessMaintenance of cellular fitnessEndoplasmic reticulum stress response pathwayMembrane-associated isoformStress response pathwaysProtein degradation pathwaysDNA repair programsCellular stress responseRemoval of protein aggregatesProtein aggregate accumulationProteostasis maintenanceChaperone inductionHomeostasis in vivoProtein misfoldingResponse pathwaysAbstract CellsCell-to-cell interactionsProteostasisStress responseDNA damageTransferred to macrophagesAggregate accumulationProtein
1998
MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway C. MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways. Molecular Cell 1998, 2: 253-258. PMID: 9734363, DOI: 10.1016/s1097-2765(00)80136-7.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationDrosophilaDrosophila ProteinsHumansInterleukin-1 Receptor-Associated KinasesMembrane GlycoproteinsMembrane ProteinsMyeloid Differentiation Factor 88NF-kappa BProtein KinasesProteinsReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Signal TransductionTNF Receptor-Associated Factor 6Toll-Like ReceptorsTranscription Factor AP-1ConceptsIL-1R familyNF-kappaB activationNF-kappaB pathwayImmune response genesToll/IL-1R familyAP-1 activationImmune responseIL-1RTRAF6 proteinInnate immunityNF-kappaBMyD88Drosophila Toll proteinReceptor familyToll receptorAdaptor proteinSignaling pathwaysReceptorsActivationToll proteinRegulator moleculesResponse genesAdult DrosophilaPathwayProtein
1997
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov R, Preston-Hurlburt P, Janeway C. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388: 394-397. PMID: 9237759, DOI: 10.1038/41131.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsB7-1 AntigenCell LineCloning, MolecularDrosophilaDrosophila ProteinsHumansImmunityInsect ProteinsInterleukinsJurkat CellsMembrane GlycoproteinsMembrane ProteinsMiceMolecular Sequence DataMutationNF-kappa BReceptors, Cell SurfaceReceptors, ImmunologicRecombinant Fusion ProteinsSequence Homology, Amino AcidSignal TransductionT-LymphocytesToll-Like ReceptorsTransfectionConceptsDrosophila Toll proteinToll proteinCytoplasmic domainDrosophila TollHuman homologueLeucine-rich repeat domainNF-κB-controlled genesHuman cell linesRepeat domainActive mutantExtracellular domainNF-κBImmune responseInnate immune responseCo-stimulatory molecules B7.1Adaptive immune systemComponents of immunityInflammatory cytokines IL-1ProteinCell linesCo-stimulatory moleculesAntigen-presenting cellsAdaptive immune responsesNaive T cellsHomologues
1992
The role of ATPase activity in the function of molecular chaperones and some regulatory proteins.
Medzhitov R. The role of ATPase activity in the function of molecular chaperones and some regulatory proteins. Биохимия 1992, 57: 1611-7. PMID: 1362654.Peer-Reviewed Original Research
1991
Evolution of regulatory proteins.
Medzhitov R. Evolution of regulatory proteins. Биохимия 1991, 56: 3-8. PMID: 1713794.Peer-Reviewed Original Research