2024
Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains
Zhu B, Park J, Coffey S, Russo A, Hsu I, Wang J, Su C, Chang R, Lam T, Gopal P, Ginsberg S, Zhao H, Hafler D, Chandra S, Zhang L. Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains. Science Translational Medicine 2024, 16: eabo1997. PMID: 39475571, DOI: 10.1126/scitranslmed.abo1997.Peer-Reviewed Original ResearchConceptsProteomic analysisAlzheimer's diseasePrefrontal cortexBrain cell typesGenetics of PDParkinson's diseaseCell-cell interactionsChaperone expressionSingle-nucleus transcriptomesExpressed genesTranscriptional changesPostmortem human brainPostmortem brain tissueDiseased brainSynaptic proteinsSingle-cellDown-regulationBrain cell populationsBrain regionsCell typesNeurodegenerative disordersLate-stage PDParkinson's disease brainsDisease etiologyNeuronal vulnerability
2023
Sensory neurons promote immune homeostasis in the lung
Tamari M, Del Bel K, Ver Heul A, Zamidar L, Orimo K, Hoshi M, Trier A, Yano H, Yang T, Biggs C, Motomura K, Shibuya R, Yu C, Xie Z, Iriki H, Wang Z, Auyeung K, Damle G, Demircioglu D, Gregory J, Hasson D, Dai J, Chang R, Morita H, Matsumoto K, Jain S, Van Dyken S, Milner J, Bogunovic D, Hu H, Artis D, Turvey S, Kim B. Sensory neurons promote immune homeostasis in the lung. Cell 2023, 187: 44-61.e17. PMID: 38134932, PMCID: PMC10811756, DOI: 10.1016/j.cell.2023.11.027.Peer-Reviewed Original ResearchCardiovascular Brain Circuits
Mohanta S, Yin C, Weber C, Godinho-Silva C, Veiga-Fernandes H, Xu Q, Chang R, Habenicht A. Cardiovascular Brain Circuits. Circulation Research 2023, 132: 1546-1565. PMID: 37228235, PMCID: PMC10231443, DOI: 10.1161/circresaha.123.322791.Peer-Reviewed Original ResearchConceptsCardiovascular systemBrain circuitsAxonal connectionsCardiovascular disease progressionIntegration centerDistant brain regionsDistinct sensory neuronsEffector neuronsAfferent inputPeripheral organsDisease progressionHormone releaseSensory neuronsImmune memoryNervous systemBrain centersImmune systemBrain regionsEfferent signalsHumoral cuesDisease hypothesisArterial treeNeuronsBrainCircuit hypothesisThe vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine
Rajendran P, Hadaya J, Khalsa S, Yu C, Chang R, Shivkumar K. The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine. Seminars In Cell And Developmental Biology 2023, 156: 190-200. PMID: 36641366, PMCID: PMC10336178, DOI: 10.1016/j.semcdb.2023.01.001.Peer-Reviewed Original ResearchConceptsParasympathetic nervous systemNervous systemEvolutionary insightsGenetic diversityComparative biologySympathetic nervous systemParasympathetic dysfunctionVagal neuronsBlood pressureVagal efferentsAfferent innervationVagus nerveHeart diseaseCardiovascular functionCardiovascular diseaseHeart rateTherapeutic potentialCardiovascular physiologyDiseaseClinical medicineHeartBiologyDiversityInnervationNerve
2018
An evolutionarily conserved gene family encodes proton-selective ion channels
Tu YH, Cooper AJ, Teng B, Chang RB, Artiga DJ, Turner HN, Mulhall EM, Ye W, Smith AD, Liman ER. An evolutionarily conserved gene family encodes proton-selective ion channels. Science 2018, 359: 1047-1050. PMID: 29371428, PMCID: PMC5845439, DOI: 10.1126/science.aao3264.Peer-Reviewed Original ResearchConceptsProton-selective ion channelIon channelsProton channelComparative transcriptome analysisTaste receptor cellsWidespread tissue distributionEvolutionary conservationEukaryotic cellsGene familyMurine geneTranscriptome analysisReceptor cellsElectrical signalingProton conductanceBroader roleMouse taste receptor cellsTissue distributionCellsOrthologsGenesSignalingProteinConservationPhysiologyFamily